Original Article

Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Corresponding Author

Masashi Koto MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

Corresponding author: M. Koto, Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku 263-8555 Chiba, Japan. E-mail: [email protected]Search for more papers by this author

Azusa Hasegawa DDS, PhD,

Azusa Hasegawa DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Ryo Takagi DDS, PhD,

Ryo Takagi DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Go Sasahara MD, PhD,

Go Sasahara MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Hiroaki Ikawa DDS, PhD,

Hiroaki Ikawa DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Jun-etsu Mizoe MD, PhD,

Jun-etsu Mizoe MD, PhD

Nagoya Proton Therapy Center, Nagoya, Japan

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Keiichi Jingu MD, PhD,

Keiichi Jingu MD, PhD

Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan

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Hirohiko Tsujii MD, PhD,

Hirohiko Tsujii MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Tadashi Kamada MD, PhD,

Tadashi Kamada MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Yoshitaka Okamoto MD, PhD,

Yoshitaka Okamoto MD, PhD

Department of Otolaryngology, Chiba University School of Medicine, Chiba, Japan

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Organizing Committee for the Working Group for Head and Neck Cancer,

Organizing Committee for the Working Group for Head and Neck Cancer

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Masashi Koto MD, PhD,

Corresponding Author

Masashi Koto MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

Azusa Hasegawa DDS, PhD,

Azusa Hasegawa DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Ryo Takagi DDS, PhD,

Ryo Takagi DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Go Sasahara MD, PhD,

Go Sasahara MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Hiroaki Ikawa DDS, PhD,

Hiroaki Ikawa DDS, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Jun-etsu Mizoe MD, PhD,

Jun-etsu Mizoe MD, PhD

Nagoya Proton Therapy Center, Nagoya, Japan

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Keiichi Jingu MD, PhD,

Keiichi Jingu MD, PhD

Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, Japan

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Hirohiko Tsujii MD, PhD,

Hirohiko Tsujii MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Tadashi Kamada MD, PhD,

Tadashi Kamada MD, PhD

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan

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Yoshitaka Okamoto MD, PhD,

Yoshitaka Okamoto MD, PhD

Department of Otolaryngology, Chiba University School of Medicine, Chiba, Japan

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Organizing Committee for the Working Group for Head and Neck Cancer,

Organizing Committee for the Working Group for Head and Neck Cancer

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First published: 28 October 2014

https://doi.org/10.1002/hed.23905

Citations: 24

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Abstract

Background

The prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C-ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C-ion RT for locally advanced SCC of the external auditory canal and middle ear.

Methods

The cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C-ion RT as the primary treatment were reviewed.

Results

The median follow-up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1-year and 3-year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients.

Conclusion

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Volume38, Issue4

April 2016

Pages 512-516

Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear

Abstract

Background

Methods

Results

Conclusion

REFERENCES

Citing Literature

References

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