Arthritis is associated with an increased risk of incident diabetes in Chinese adults: A nationwide cohort study and updated meta-analysis
Xue Yang
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorYue Xie
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorYi Wang
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Search for more papers by this authorYong Yu
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorXingzhong Jin
Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia
Search for more papers by this authorPeng Xiu
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorJason H. Y. Wu
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
Search for more papers by this authorDanxia Yu
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Search for more papers by this authorAn Pan
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Search for more papers by this authorJian Zhao
The Ministry of Education - Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Chun-Xia Yang
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Correspondence
Chun-Xia Yang, 3-17 Renmin Nanlu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Xiong-Fei Pan, 2525 West End Avenue, Suite. 600, Nashville, Tennessee 37203, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Xiong-Fei Pan
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Correspondence
Chun-Xia Yang, 3-17 Renmin Nanlu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Xiong-Fei Pan, 2525 West End Avenue, Suite. 600, Nashville, Tennessee 37203, USA.
Email: [email protected]
Search for more papers by this authorXue Yang
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorYue Xie
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorYi Wang
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Search for more papers by this authorYong Yu
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorXingzhong Jin
Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia
Search for more papers by this authorPeng Xiu
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Search for more papers by this authorJason H. Y. Wu
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
Search for more papers by this authorDanxia Yu
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Search for more papers by this authorAn Pan
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Search for more papers by this authorJian Zhao
The Ministry of Education - Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Chun-Xia Yang
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China
Correspondence
Chun-Xia Yang, 3-17 Renmin Nanlu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Xiong-Fei Pan, 2525 West End Avenue, Suite. 600, Nashville, Tennessee 37203, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Xiong-Fei Pan
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Correspondence
Chun-Xia Yang, 3-17 Renmin Nanlu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Xiong-Fei Pan, 2525 West End Avenue, Suite. 600, Nashville, Tennessee 37203, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Aims
To prospectively examine the association between arthritis and type 2 diabetes (T2D) in the Chinese population and confirm this association through a comprehensive meta-analysis of cohort studies.
Meterials and Methods
Data were from the China Health and Retirement Longitudinal Study which was started in 2011–2013 and followed up in 2013–2014 and 2015–2016. Arthritis was defined as self-reported physician diagnosis at baseline, and incident T2D was determined by self-reported physician diagnosis, fasting blood glucose ≥7.0 mmol/L or glycosylated haemoglobin ≥6.5% during the follow-ups. Cox proportional hazards regression models were used to assess the association between arthritis and risk for T2D. A meta-analysis was conducted to pool our effect estimate and those from other cohort studies using a random-effects model.
Results
Eleven thousand four hundred and eight participants (47.9% men; mean age: 59.3 years) were included in final analyses. During a 4-year follow-up, 981 participants reported incident T2D. Compared with individuals without arthritis, those with arthritis at baseline had an 18% higher risk for incident T2D (multivariable-adjusted hazard ratio: 1.18; 95% confidence interval: 1.04, 1.34). In the meta-analysis of 13 cohort studies including ours, a total of 2,473,514 participants were included with 121,851 incident diabetes. The pooling HR was 1.32 (95% CI: 1.21, 1.44) for the association between arthritis and diabetes.
Conclusion
Arthritis was associated with an increased risk of incident diabetes in Chinese adults, and the positive association was confirmed in the meta-analysis of cohort studies. Our work can inform clinical trials to assess the effectiveness of arthritis treatments in reducing risk of diabetes.
CONFLICTS OF INTEREST
The authors declare that they have no competing interest.
Open Research
DATA AVAILABILITY STATEMENT
The CHARLS data sets are available from the official website of CHARLS.
Supporting Information
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| dmrr3487-sup-0001-suppl-data.docx219.8 KB | Supporting Information 1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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