Symposium Issue
Molecular genetic characterization of lymphoma: Application to cytology diagnosis
Rachel C. Ochs M.D.,
Adam Bagg M.D.,
Rachel C. Ochs M.D.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Search for more papers by this authorCorresponding Author
Adam Bagg M.D.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PASearch for more papers by this authorRachel C. Ochs M.D.,
Adam Bagg M.D.,
Rachel C. Ochs M.D.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Search for more papers by this authorCorresponding Author
Adam Bagg M.D.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PASearch for more papers by this authorAbstract
Mature B- and T-cell lymphomas are increasingly being associated with specific genetic alterations; characterization of these changes can sometimes be crucial to both diagnosis and prognosis. Molecular testing encompasses florescence in situ hybridization (FISH) and polymerase chain reaction (PCR)-based assays, as well as classical cytogenetics. FISH and PCR-based assays can be performed on cytology material without the need for advanced planning for testing with fresh tissue. As many lymphoproliferations are amenable to fine needle aspiration diagnosis, it is important for the cytopathologist to be aware of what testing is feasible in these (sometimes limited) specimens. Here, we review pertinent genetic changes in mature B- and T-cell lymphomas with a focus on those that may be encountered more commonly in cytology specimens. Diagn. Cytopathol. 2012;40:542–555. © 2012 Wiley Periodicals, Inc.
References
- 1Stoos-VeicT,LivunA,AjdukovicR,PejsaV,JaksicO,KusecR.Detection of t(14;18) by PCR of IgH/BCL2 fusion gene in follicular lymphoma from archived cytological smears.Coll Antropol 2010; 34: 425–429.
- 2da Cunha SantosG,KoHM,GeddieWR, et al.Targeted use of fluorescence in situ hybridization (FISH) in cytospin preparations: Results of 298 fine needle aspirates of B-cell non-Hodgkin lymphoma.Cancer Cytopathol 2010; 118: 250–258.
- 3KillianJK,WalkerRL,SuuriniemiM, et al.Archival fine-needle aspiration cytopathology (FNAC) samples: Untapped resource for clinical molecular profiling.J Mol Diagn 2010; 12: 739–745.
- 4MonacoSE,TeotLA,FelgarRE,SurtiU,CaiG.Fluorescence in situ hybridization studies on direct smears: An approach to enhance the fine-needle aspiration biopsy diagnosis of B-cell non-Hodgkin lymphomas.Cancer 2009; 117: 338–348.
- 5SafleyAM,BuckleyPJ,CreagerAJ, et al.The value of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration.Arch Pathol Lab Med 2004; 128: 1395–1403.
- 6SchmidS,TinguelyM,CioneP,MochH,BodeB.Flow cytometry as an accurate tool to complement fine needle aspiration cytology in the diagnosis of low grade malignant lymphomas.Cytopathology 2011; 22:397–406.
- 7BangerterM,BrudlerO,HeinrichB,GriesshamnuerM.Fine needle aspiration cytology and flow cytometry in the diagnosis and subclassification of non-Hodgkin's lymphoma based on the World Health Organization classification.Acta Cytol 2007; 51: 390–398.
- 8DemurtasA,AccinelliG,PacchioniD, et al.Utility of flow cytometry immunophenotyping in fine-needle aspirate cytologic diagnosis of non-Hodgkin lymphoma: A series of 252 cases and review of the literature.Appl Immunohistochem Mol Morphol 2010; 18: 311–322.
- 9LiuK,SternRC,RogersRT,DoddLG,MannKP.Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: A review of 127 cases.Diagn Cytopathol 2001; 24: 1–10.
- 10BaggA.Immunoglobulin and T-cell receptor gene rearrangements: Minding your B's and T's in assessing lineage and clonality in neoplastic lymphoproliferative disorders.J Mol Diagn 2006; 8: 426–429; quiz526–527.
- 11RoulletM,BaggA.The basis and rational use of molecular genetic testing in mature B-cell lymphomas.Adv Anat Pathol 2010; 17: 333–358.
- 12JaffeES,BanksPM,NathwaniB,SaidJ,SwerdlowSH.Recommendations for the reporting of lymphoid neoplasms: A report from the Association of Directors of Anatomic and Surgical Pathology.Mod Pathol 2004; 17: 131–135.
- 13MarotoA,MartinezM,MartinezMA,de AgustinP,Rodriguez-PeraltoJL.Comparative analysis of immunoglobulin polymerase chain reaction and flow cytometry in fine needle aspiration biopsy differential diagnosis of non-Hodgkin B-cell lymphoid malignancies.Diagn Cytopathol 2009; 37: 647–653.
- 14ZhangS,AbreoF,Lowery-NordbergM,VeillonDM,CotelingamJD.The role of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis and classification of lymphoproliferative disorders on fine-needle aspiration.Cancer Cytopathol 2010; 118: 105–112.
- 15VenkatramanL,CatherwoodMA,PattersonA,LioeTF,McCluggageWG,AndersonNH.Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations.J Clin Pathol 2006; 59: 1160–1165.
- 16de LevalL,HasserjianRP.Diffuse large B-cell lymphomas and burkitt lymphoma.Hematol Oncol Clin North Am 2009; 23: 791–827.
- 17A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project.Blood 1997; 89: 3909–3918.
- 18 SH Swerdlow, E Campo, NL Harris, et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. International agency for research on cancer, Lyon, France, 2008.
- 19AlizadehAA,EisenMB,DavisRE, et al.Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.Nature 2000; 403: 503–511.
- 20RosenwaldA,WrightG,ChanWC, et al.The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.N Engl J Med 2002; 346: 1937–1947.
- 21HansCP,WeisenburgerDD,GreinerTC, et al.Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.Blood 2004; 103: 275–282.
- 22ChoiWW,WeisenburgerDD,GreinerTC, et al.A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy.Clin Cancer Res 2009; 15: 5494–5502.
- 23ColomoL,Lopez-GuillermoA,PeralesM, et al.Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma.Blood 2003; 101: 78–84.
- 24MeyerPN,FuK,GreinerTC, et al.Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab.J Clin Oncol 2011; 29: 200–207.
- 25MurisJJ,MeijerCJ,VosW, et al.Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma.J Pathol 2006; 208: 714–723.
- 26FuK,WeisenburgerDD,ChoiWW, et al.Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma.J Clin Oncol 2008; 26: 4587–4594.
- 27Gutierrez-GarciaG,Cardesa-SalzmannT,ClimentF, et al.Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.Blood 2011; 117: 4836–4843.
- 28OttG,ZiepertM,KlapperW, et al.Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL.Blood 2010; 116: 4916–4925.
- 29IqbalJ,MeyerPN,SmithL, et al.BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab.Clin Cancer Res, in press.
- 30PasqualucciL,MigliazzaA,BassoK,HouldsworthJ,ChagantiRS,Dalla-FaveraR.Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.Blood 2003; 101: 2914–2923.
- 31ShustikJ,HanG,FarinhaP, et al.Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP.Haematologica 2010; 95: 96–101.
- 32TzankovA,SchneiderA,HoellerS,DirnhoferS.Prognostic importance of BCL6 rearrangements in diffuse large B-cell lymphoma with respect to Bcl6 protein levels and primary lymphoma site.Hum Pathol 2009; 40: 1055–1056; author reply1056.
- 33ChangCM,SchroederJC,HuangWY, et al.Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case-control study.Leuk Res 2010; 34: 190–195.
- 34HiroseY,MasakiY,KarasawaH, et al.Incidence of diffuse large B-cell lymphoma of germinal center B-cell origin in whole diffuse large B-cell lymphoma: Tissue fluorescence in situ hybridization using t(14;18) compared with immunohistochemistry.Int J Hematol 2005; 81: 48–57.
- 35TibilettiMG,MartinV,BernasconiB, et al.BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: A multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome.Hum Pathol 2009; 40: 645–652.
- 36BarransS,CrouchS,SmithA, et al.Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab.J Clin Oncol 2010; 28: 3360–3365.
- 37ElkinsCT,WakelyPE,Jr.Cytopathology of "double-hit" non-Hodgkin lymphoma.Cancer Cytopathol 2011; 119: 263–271.
- 38AsterJC,LongtineJA.Detection of BCL2 rearrangements in follicular lymphoma.Am J Pathol 2002; 160: 759–763.
- 39GollubW,StassekB,HuckhagelT, et al.BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2.Anticancer Res 2009; 29: 4649–4655.
- 40BaconCM,YeH,DissTC, et al.Primary follicular lymphoma of the testis and epididymis in adults.Am J Surg Pathol 2007; 31: 1050–1058.
- 41SwerdlowSH.Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia.Am J Clin Pathol 2004; 122 (Suppl): S98–S109.
- 42AguileraNS,TomaszewskiMM,MoadJC,BauerFA,TaubenbergerJK,AbbondanzoSL.Cutaneous follicle center lymphoma: A clinicopathologic study of 19 cases.Mod Pathol 2001; 14: 828–835.
- 43MirzaI,MacphersonN,PaproskiS, et al.Primary cutaneous follicular lymphoma: An assessment of clinical, histopathologic, immunophenotypic, and molecular features.J Clin Oncol 2002; 20: 647–655.
- 44RichmondJ,BryantR,TrotmanW,BeattyB,LundeJ.FISH detection of t(14;18) in follicular lymphoma on Papanicolaou-stained archival cytology slides.Cancer 2006; 108: 198–204.
- 45BaroC,EspinetB,SalidoM, et al.Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma.Leuk Res 2011; 35: 256–259.
- 46DohnerH,StilgenbauerS,BennerA, et al.Genomic aberrations and survival in chronic lymphocytic leukemia.N Engl J Med 2000; 343: 1910–1916.
- 47MigliazzaA,BoschF,KomatsuH, et al.Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.Blood 2001; 97: 2098–2104.
- 48DickerF,HerholzH,SchnittgerS, et al.The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype.Leukemia 2009; 23: 117–124.
- 49TrbusekM,SmardovaJ,MalcikovaJ, et al.Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemia.J Clin Oncol 2011; 29: 2703–2708.
- 50HallekM,ChesonBD,CatovskyD, et al.Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.Blood 2008; 111: 5446–5456.
- 51CarawayNP,GuJ,LinP,RomagueraJE,GlassmanA,KatzR.The utility of interphase fluorescence in situ hybridization for the detection of the translocation t(11;14)(q13;q32) in the diagnosis of mantle cell lymphoma on fine-needle aspiration specimens.Cancer 2005; 105: 110–118.
- 52HamblinTJ,DavisZ,GardinerA,OscierDG,StevensonFK.Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.Blood 1999; 94: 1848–1854.
- 53DamleRN,WasilT,FaisF, et al.Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.Blood 1999; 94: 1840–1847.
- 54CrespoM,BoschF,VillamorN, et al.ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.N Engl J Med 2003; 348: 1764–1775.
- 55RoulletM,SargentR,PashaT, et al.ZAP70 expression assessed by immunohistochemistry on peripheral blood: A simple prognostic assay for patients with chronic lymphocytic leukemia.Appl Immunohistochem Mol Morphol 2007; 15: 471–476.
- 56AbboudiZ,PatelK,NareshKN.Cyclin D1 expression in typical chronic lymphocytic leukaemia.Eur J Haematol 2009; 83: 203–207.
- 57BentzJS,RoweLR,AndersonSR,GuptaPK,McGrathCM.Rapid detection of the t(11;14) translocation in mantle cell lymphoma by interphase fluorescence in situ hybridization on archival cytopathologic material.Cancer 2004; 102: 124–131.
- 58WlodarskaI,DierickxD,VanhentenrijkV, et al.Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.Blood 2008; 111: 5683–5690.
- 59MetcalfRA,ZhaoS,AndersonMW, et al.Characterization of D-cyclin proteins in hematolymphoid neoplasms: Lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes.Mod Pathol 2010; 23: 420–433.
- 60ChenYH,GaoJ,FanG,PetersonLC.Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms.Mod Pathol 2010; 23: 105–112.
- 61MozosA,RoyoC,HartmannE, et al.SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.Haematologica 2009; 94: 1555–1562.
- 62SuarezF,LortholaryO,HermineO,LecuitM.Infection-associated lymphomas derived from marginal zone B cells: A model of antigen-driven lymphoproliferation.Blood 2006; 107: 3034–3044.
- 63RemsteinED,DoganA,EinersonRR, et al.The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America.Am J Surg Pathol 2006; 30: 1546–1553.
- 64LiuH,YeH,Ruskone-FourmestrauxA, et al.T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication.Gastroenterology 2002; 122: 1286–1294.
- 65RemsteinED,KurtinPJ,JamesCD,WangXY,MeyerRG,DewaldGW.Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.Am J Pathol 2002; 161: 63–71.
- 66ZhangW,GarcesJ,DongHY.Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.Am J Clin Pathol 2006; 126: 931–940.
- 67DierlammJ,BaensM,Stefanova-OuzounovaM, et al.Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes.Blood 2000; 96: 2215–2218.
- 68KobayashiY,NakataM,MaekawaM, et al.Detection of t(I 1; 18) in MALT-type lymphoma with dual-color fluorescence in situ hybridization and reverse transcriptase-polymerase chain reaction analysis.Diagn Mol Pathol 2001; 10: 207–213.
- 69StreubelB,LamprechtA,DierlammJ, et al.T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.Blood 2003; 101: 2335–2339.
- 70StreubelB,VinatzerU,LamprechtA,RadererM,ChottA.T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.Leukemia 2005; 19: 652–658.
- 71SagaertX,LaurentM,BaensM,WlodarskaI,de Wolf-PeetersC.MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells.Mod Pathol 2006; 19: 225–232.
- 72HsiED,GreensonJK,SingletonTP,SiddiquiJ,SchnitzerB,RossCW.Detection of immunoglobulin heavy chain gene rearrangement by polymerase chain reaction in chronic active gastritis associated with Helicobacter pylori.Hum Pathol 1996; 27: 290–296.
- 73ZeppaP,CozzolinoI,PelusoAL, et al.Cytologic, flow cytometry, and molecular assessment of lymphoid infiltrate in fine-needle cytology samples of Hashimoto thyroiditis.Cancer 2009; 117: 174–184.
- 74PiccalugaPP,de FalcoG,KustagiM, et al.Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes.Blood 2011; 117: 3596–3608.
- 75BoermaEG,SiebertR,KluinPM,BaudisM.Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: A historical review of cytogenetics in the light of todays knowledge.Leukemia 2009; 23: 225–234.
- 76LossosIS.Molecular pathogenesis of diffuse large B-cell lymphoma.J Clin Oncol 2005; 23: 6351–6357.
- 77HummelM,BentinkS,BergerH, et al.A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.N Engl J Med 2006; 354: 2419–2430.
- 78SalaverriaI,SiebertR.The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective.J Clin Oncol 2011; 29: 1835–1843.
- 79RapkiewiczA,WenH,SenF,DasK.Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology.Cancer 2007; 111: 499–507.
- 80NgWK,IpP,ChoyC,CollinsRJ.Cytologic and immunocytochemical findings of anaplastic large cell lymphoma: Analysis of ten fine-needle aspiration specimens over a 9-year period.Cancer 2003; 99: 33–43.
- 81MedeirosLJ,Elenitoba-JohnsonKS.Anaplastic large cell lymphoma.Am J Clin Pathol 2007; 127: 707–722.
- 82DasDK.Serous effusions in malignant lymphomas: A review.Diagn Cytopathol 2006; 34: 335–347.
- 83OngKC,IndumathiV,PohWT,OngYY.The diagnostic yield of pleural fluid cytology in malignant pleural effusions.Singapore Med J 2000; 41: 19–23.
- 84JohnstonWW.The malignant pleural effusion. A review of cytopathologic diagnoses of 584 specimens from 472 consecutive patients.Cancer
1985; 56: 905–909.
10.1002/1097-0142(19850815)56:4<905::AID-CNCR2820560435>3.0.CO;2-U CAS PubMed Web of Science® Google Scholar
- 85OkadaF,AndoY,KondoY,MatsumotoS,MaedaT,MoriH.Thoracic CT findings of adult T-cell leukemia or lymphoma.AJR Am J Roentgenol 2004; 182: 761–767.
- 86CarboneA,GloghiniA,VaccherE,MarchettiG,GaidanoG,TirelliU.KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype.J Clin Pathol 2005; 58: 1039–1045.
- 87BrimoF,MichelRP,KhetaniK,AugerM.Primary effusion lymphoma: A series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis.Cancer 2007; 111: 224–233.
- 88BoulangerE,AgbalikaF,MaarekO, et al.A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.Hematol J 2001; 2: 172–179.
- 89LoboC,AminS,RamsayA,DissT,KocjanG.Serous fluid cytology of multicentric Castleman's disease and other lymphoproliferative disorders associated with Kaposi sarcoma-associated herpes virus: A review with case reports.Cytopathology, in press.
- 90CesarmanE,ChangY,MoorePS,SaidJW,KnowlesDM.Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.N Engl J Med 1995; 332: 1186–1191.
- 91GuptaN,NijhawanR,SrinivasanR, et al.Fine needle aspiration cytology of primary thyroid lymphoma: A report of ten cases.Cytojournal 2005; 2: 21.
- 92DerringerGA,ThompsonLD,FrommeltRA,BijwaardKE,HeffessCS,AbbondanzoSL.Malignant lymphoma of the thyroid gland: A clinicopathologic study of 108 cases.Am J Surg Pathol 2000; 24: 623–639.
- 93WatanabeN,NohJY,NarimatsuH, et al.Clinicopathological features of 171 cases of primary thyroid lymphoma: A long-term study involving 24,553 patients with Hashimoto's disease.Br J Haematol, in press.
- 94WidderS,PasiekaJL.Primary thyroid lymphomas.Curr Treat Options Oncol 2004; 5: 307–313.
- 95KabaS,HirokawaM,KumaS, et al.Cytologic findings of primary thyroid MALT lymphoma with extreme plasma cell differentiation: FNA cytology of two cases.Diagn Cytopathol 2009; 37: 815–819.
- 96Al-MarzooqYM,ChopraR,YounisM,Al-MulhimAS,Al-MommattenMI,Al-OmranSH.Thyroid low-grade B-cell lymphoma (MALT type) with extreme plasmacytic differentiation: Report of a case diagnosed by fine-needle aspiration and flow cytometric study.Diagn Cytopathol 2004; 31: 52–56.
- 97KojimaM,NakamuraN,ShimizuK,SegawaA,KabaS,MasawaN.MALT type lymphoma demonstrating prominent plasma cell differentiation resembling fibrous variant of Hashimoto's thyroiditis: A three case report.Pathol Oncol Res 2009; 15: 285–289.
- 98ChenHI,AkpolatI,ModyDR, et al.Restricted κ/λ light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditis.Am J Clin Pathol 2006; 125: 42–48.
- 99MatsubayashiS,TamaiH,MoritaT, et al.Hashimoto's thyroiditis manifesting monoclonal lymphocytic infiltration.Clin Exp Immunol 1990; 79: 170–174.
- 100SaxenaA,AlportEC,MoshynskaO,KanthanR,BoctorMA.Clonal B cell populations in a minority of patients with Hashimoto's thyroiditis.J Clin Pathol 2004; 57: 1258–1263.
- 101HsiED,SingletonTP,SvobodaSM,SchnitzerB,RossCW.Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain gene rearrangement.Am J Clin Pathol 1998; 110: 327–333.
- 102MoshynskaOV,SaxenaA.Clonal relationship between Hashimoto thyroiditis and thyroid lymphoma.J Clin Pathol 2008; 61: 438–444.
- 103GoatlyA,BaconCM,NakamuraS, et al.FOXP1 abnormalities in lymphoma: Translocation breakpoint mapping reveals insights into deregulated transcriptional control.Mod Pathol 2008; 21: 902–911.
- 104GholamD,BibeauF,El WeshiA,BosqJ,RibragV.Primary breast lymphoma.Leuk Lymphoma 2003; 44: 1173–1178.
- 105JeonHJ,AkagiT,HoshidaY, et al.Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan.Cancer
1992; 70: 2451–2459.
10.1002/1097-0142(19921115)70:10<2451::AID-CNCR2820701011>3.0.CO;2-B PubMed Web of Science® Google Scholar
- 106CohenPL,BrooksJJ.Lymphomas of the breast. A clinicopathologic and immunohistochemical study of primary and secondary cases.Cancer
1991; 67: 1359–1369.
10.1002/1097-0142(19910301)67:5<1359::AID-CNCR2820670515>3.0.CO;2-4 CAS PubMed Web of Science® Google Scholar
- 107ThompsonPA,LadeS,WebsterH,RyanG,PrinceHM.Effusion-associated anaplastic large cell lymphoma of the breast: Time for it to be defined as a distinct clinico-pathological entity.Haematologica 2010; 95: 1977–1979.
- 108RodenAC,MaconWR,KeeneyGL,MyersJL,FeldmanAL,DoganA.Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: An indolent T-cell lymphoproliferative disorder.Mod Pathol 2008; 21: 455–463.
- 109de JongD,VasmelWL,de BoerJP, et al.Anaplastic large-cell lymphoma in women with breast implants.JAMA 2008; 300: 2030–2035.
- 110Al-KhafajiBM,NestokBR,KatzRL.Fine-needle aspiration of 154 parotid masses with histologic correlation: Ten-year experience at the University of Texas M. D. Anderson Cancer Center.Cancer
1998; 84: 153–159.
10.1002/(SICI)1097-0142(19980625)84:3<153::AID-CNCR6>3.0.CO;2-P CAS PubMed Web of Science® Google Scholar
- 111TrochM,FormanekM,StreubelB,MullauerL,ChottA,RadererM.Clinicopathological aspects of mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland: A retrospective single-center analysis of 28 cases.Head Neck 2011; 33: 763–767.
- 112ZenoneT.Parotid gland non-Hodgkin lymphoma in primary Sjogren syndrome.Rheumatol Int, in press.
- 113KassanSS,ThomasTL,MoutsopoulosHM, et al.Increased risk of lymphoma in sicca syndrome.Ann Intern Med 1978; 89: 888–892.
- 114InagakiH.Mucosa-associated lymphoid tissue lymphoma: Molecular pathogenesis and clinicopathological significance.Pathol Int 2007; 57: 474–484.
- 115BaimpaE,DahabrehIJ,VoulgarelisM,MoutsopoulosHM.Hematologic manifestations and predictors of lymphoma development in primary Sjogren syndrome: Clinical and pathophysiologic aspects.Medicine (Baltimore) 2009; 88: 284–293.
- 116Amador-OrtizC,ChenL,HassanA, et al.Combined core needle biopsy and fine-needle aspiration with ancillary studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma.Am J Clin Pathol 2011; 135: 516–524.
- 117KatzRL.Modern approach to lymphoma diagnosis by fine-needle aspiration: Restoring respect to a valuable procedure.Cancer 2005; 105: 429–431.
- 118CarawayNP.Strategies to diagnose lymphoproliferative disorders by fine-needle aspiration by using ancillary studies.Cancer 2005; 105: 432–442.
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