Selective Synthesis of Bromo-substituted 2H-Pyrroles and 3H-Pyrroles via Three-Component Cascade Annulation of 1,3-Enynes, NBS and TMSN3
Zhen Zhang
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorQingting Song
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorFan Qin
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorHan Yue
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorCorresponding Author
Xiaoyu Xie
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorLei Wang
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorCorresponding Author
Tao Miao
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorZhen Zhang
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorQingting Song
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorFan Qin
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorHan Yue
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Search for more papers by this authorCorresponding Author
Xiaoyu Xie
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorLei Wang
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
Advanced Research Institute and Department of Chemistry, Taizhou University, Taizhou, Zhejiang, 318000 China
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, 311121 China
Search for more papers by this authorCorresponding Author
Tao Miao
Key Laboratory of Green and Precise Synthetic Chemistry and Application, Ministry of Education; Anhui Key Laboratory of Synthetic Chemistry and Applications, Huaibei Normal University, Huaibei, Anhui, 235000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
A novel and efficient method for selective synthesis of bromo-substituted 2H-pyrroles and 3H-pyrroles has been achieved from 1,3-enynes, NBS and TMSN3 via H2O-promoted cyclization reactions or TFA-catalyzed cyclization/2,3-shift reactions, providing a range of structurally diverse products in moderate to good yields under mild conditions.
Supporting Information
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Appendix S1: Supporting Information |
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