An Intelligent Triple Assisted Gold Cluster-Based Nanosystem for Enhanced Tumor Photodynamic Therapy
Fangli Gao
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
These authors contributed equally.
Search for more papers by this authorYanru Liu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
These authors contributed equally.
Search for more papers by this authorLiang Zhu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorCorresponding Author
Jie Zhang
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorYi Chang
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorWeihua Gao
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorGuanglei Ma
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorCorresponding Author
Xiaoming Ma
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yuming Guo
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorFangli Gao
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
These authors contributed equally.
Search for more papers by this authorYanru Liu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
These authors contributed equally.
Search for more papers by this authorLiang Zhu
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorCorresponding Author
Jie Zhang
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorYi Chang
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorWeihua Gao
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorGuanglei Ma
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
Search for more papers by this authorCorresponding Author
Xiaoming Ma
Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yuming Guo
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007 China
Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Xinxiang, Henan, 453007 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Photodynamic therapy (PDT) has been attracted a surge of research interest. However, there are several obstacles to limit the efficacy of PDT, such as hypoxic tumor microenvironment (TME), overexpressed glutathione (GSH), inefficient reactive oxygen species (ROS) generation, and so on. Herein, a smart responsive nanosystem was constructed, which was composed of Au25 modified with triphenylphosphine (Au25-TPP), catalase (CAT) and GSH-responsive diselenide-bridged mesoporous silica nanoparticles (Se-MSN). When the nanosystem arrived at tumor site, Se-MSN was degraded by the intracellular overexpressed GSH to release Au25-TPP and CAT. The Au25-TPP was targeted to mitochondria and generated ROS under the 808 nm NIR laser irradiation to kill tumor cells. Simultaneously, CAT could catalyze hydrogen peroxide to provide oxygen for relieving the hypoxia of TME. Besides, GSH was consumed by the diselenide bond to diminish the ROS loss. The above tactics (mitochondria targeting, hypoxia relieving and GSH consuming) jointly enhanced the PDT efficacy. The nanosystem showed distinct in vitro anticancer effect significantly stronger than other groups containing one or two assistance. Moreover, the in vivo results suggested that the tumors could be restrained obviously. The current study provides a new inspiration for constructing novel inorganic nanomedicines with multiple enhancement effect of PDT efficacy.
Supporting Information
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Appendix S1: Supporting Information |
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