Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis
Bao Chen
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorXia-Juan Huan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorZe-Hong Miao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorNicole J. de Voogd
Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA, Leiden, the Netherlands
Leiden University, Institute of Environmental Sciences, P.O. Box 9518, 2300 RA, Leiden, the Netherlands
Search for more papers by this authorYu-Cheng Gu
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY United Kingdom
Search for more papers by this authorCorresponding Author
Chang-Yun Wang
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yue-Wei Guo
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Xu-Wen Li
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorBao Chen
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorXia-Juan Huan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorZe-Hong Miao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Search for more papers by this authorNicole J. de Voogd
Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA, Leiden, the Netherlands
Leiden University, Institute of Environmental Sciences, P.O. Box 9518, 2300 RA, Leiden, the Netherlands
Search for more papers by this authorYu-Cheng Gu
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY United Kingdom
Search for more papers by this authorCorresponding Author
Chang-Yun Wang
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 266003 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yue-Wei Guo
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Xu-Wen Li
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203 China
Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao, Shandong, 266237 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorMain observation and conclusion
Two new bis-quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis- and trans-quinolizidine nuclei, one known related analogue petrosin (3) and three known xestospongins (4—6), were isolated from the South China Sea sponge Neopetrosia chaliniformis. The structures of new compounds were unambiguously determined by extensive spectroscopic and single-crystal X-ray analyses. In bioassay, compounds 4—6 exhibited moderate cytotoxicity against several human cancer cells.
Supporting Information
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Appendix S1: Supporting Information |
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