Concise Report
Synthesis of Phenanthridine and Quinoxaline Derivatives via Copper-Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides
Qi Liang,
Long Lin,
Guodong Li,
Xianqiang Kong,
Bo Xu,
Qi Liang
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
‡ These authors contributed equally to this work.
Search for more papers by this authorLong Lin
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
‡ These authors contributed equally to this work.
Search for more papers by this authorGuodong Li
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
Search for more papers by this authorCorresponding Author
Xianqiang Kong
School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou, Jiangsu, 213032 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Bo Xu
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
E-mail: [email protected]; [email protected]Search for more papers by this authorQi Liang,
Long Lin,
Guodong Li,
Xianqiang Kong,
Bo Xu,
Qi Liang
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
‡ These authors contributed equally to this work.
Search for more papers by this authorLong Lin
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
‡ These authors contributed equally to this work.
Search for more papers by this authorGuodong Li
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
Search for more papers by this authorCorresponding Author
Xianqiang Kong
School of Chemical Engineering and Materials, Changzhou Institute of Technology, No. 666 Liaohe Road, Changzhou, Jiangsu, 213032 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Bo Xu
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 China
E-mail: [email protected]; [email protected]Search for more papers by this authorMain observation and conclusion
A copper-catalyzed radical cyclization of cyclobutanone oxime esters and vinyl azide is described. This method provides facile access to cyanoalkyl-substituted phenanthridines and quinoxalines with excellent isolated yields. Moreover, these reactions proceed under mild conditions with a board substrate scope and excellent functional group tolerance.
Supporting Information
| Filename | Description |
|---|---|
| cjoc202100050-sup-0001-Supinfo.pdfPDF document, 3.9 MB |
Appendix S1: Supporting Information |
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