A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and H2O2 in Inflammation and Tumor Models
Corresponding Author
Li Fan
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorQi Zan
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorXiaodong Wang
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorShuohang Wang
School of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, Jilin, 132022 China
Search for more papers by this authorCorresponding Author
Yuewei Zhang
School of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, Jilin, 132022 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorWenjuan Dong
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorShaomin Shuang
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorCorresponding Author
Chuan Dong
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Li Fan
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorQi Zan
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorXiaodong Wang
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorShuohang Wang
School of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, Jilin, 132022 China
Search for more papers by this authorCorresponding Author
Yuewei Zhang
School of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin, Jilin, 132022 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorWenjuan Dong
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorShaomin Shuang
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
Search for more papers by this authorCorresponding Author
Chuan Dong
Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi, 030006 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorMain observation and conclusion
Elucidating the intrinsic relationship between viscosity/H2O2 and mitochondria-associated diseases remains a great challenge owing to the lack of research on multiple diseases models, such as inflammation and malignant tumor models. In this work, we have developed a mitochondria-specific orange/near-infrared-emissive fluorescent probe TTPB, for dual-imaging of viscosity and H2O2 levels in two different channels. The probe exhibited a remarkable response to viscosity with NIR emission round 666 nm, and was highly sensitive to H2O2 in orange channel with emission peak at 586 nm. Moreover, TTPB has good mitochondria-specific ability and permits individual detecting of viscosity in NIR channels and H2O2 levels in orange channel in living cells. More notably, TTPB was successfully applied to simultaneously image the viscosity and H2O2 levels in inflammation and cancer models.
Supporting Information
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Appendix S1: Supporting Information |
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