Monoterpenoid Indole Alkaloids with Promoting Neurite Growth from Tabernaemontana divaricata
Yan Deng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
These authors contributed to this work equally.
Search for more papers by this authorYang Yu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
These authors contributed to this work equally.
Search for more papers by this authorBao-Bao Shi
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
Search for more papers by this authorMei-Fen Bao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
Search for more papers by this authorSi-Meng Zhao
iHuman Institute, ShanghaiTech University, Shanghai, 200031 China
Search for more papers by this authorCorresponding Author
Xiang-Hai Cai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
E-mail: [email protected]Search for more papers by this authorYan Deng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
These authors contributed to this work equally.
Search for more papers by this authorYang Yu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
These authors contributed to this work equally.
Search for more papers by this authorBao-Bao Shi
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
Search for more papers by this authorMei-Fen Bao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
Search for more papers by this authorSi-Meng Zhao
iHuman Institute, ShanghaiTech University, Shanghai, 200031 China
Search for more papers by this authorCorresponding Author
Xiang-Hai Cai
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201 China
E-mail: [email protected]Search for more papers by this authorMain observation and conclusion
Phytochemical investigations on Tabernaemontana divaricata led to the isolation of seven undescribed monoterpenoid indole alkaloids, taberdicatines A—G (1—7). Taberdicatines A—C might be derived from Aspidosperma-type alkaloid, less skeletal carbons in 1—2 and an additional carbon in 3. Taberdicatines D—E (4—5) were attributed to Iboga alkaloids with enantiomeric skeleton, respectively. Alkaloid 3 could promote the neurite growth of mouse primary cortical neurons at the concentration of 5 μmol/L.
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