Sesquiterpenoids from the Whole Plants of Chloranthus holostegius and Their Anti-inflammatory Activities
Zhao-Chun Zhan
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
‡These authors contributed equally to this work.
Search for more papers by this authorZhong-Nan Wu
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632 China
‡These authors contributed equally to this work.
Search for more papers by this authorQing Tang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorCan-Jie Li
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorWen-Zhi Wang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorJi-Hui Zhang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorXue-Fang Zhuo
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorCorresponding Author
Yu-Bo Zhang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guo-Cai Wang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yao-Lan Li
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorZhao-Chun Zhan
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
‡These authors contributed equally to this work.
Search for more papers by this authorZhong-Nan Wu
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, 510632 China
‡These authors contributed equally to this work.
Search for more papers by this authorQing Tang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorCan-Jie Li
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorWen-Zhi Wang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorJi-Hui Zhang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorXue-Fang Zhuo
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Search for more papers by this authorCorresponding Author
Yu-Bo Zhang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guo-Cai Wang
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yao-Lan Li
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorMain observation and conclusion
Five new sesquiterpenoids (1—5), chloranholides A—E, along with three known compounds (6—8), were isolated from the whole plants of Chloranthus holostegius. Their structures were elucidated using the spectroscopic methods (IR, UV, HR-ESI-MS, 1D and 2D NMR), and their absolute configurations were determined by the X-ray crystallography and ECD calculation. Compounds 1—8 were evaluated for their anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells. Especially, compound 4 exhibited the most significant anti-inflammatory activity with the secretion levels of TNF-α and IL-6 at 15.52% and 5.98%, respectively, better than that of dexamethasone.
Supporting Information
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Appendix S1: Supporting Information |
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