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Synergistic Catalysis with Azomethine Ylides
Liang Wei,
Chun-Jiang Wang,
Liang Wei
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Chun-Jiang Wang
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this authorLiang Wei,
Chun-Jiang Wang,
Liang Wei
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Chun-Jiang Wang
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]Search for more papers by this authorAbstract
Azomethine ylides are useful intermediates for the rapid construction of chiral N-containing compounds. However, its synthetic potential has not been fully developed due to the limited reaction models. In combination with synergistic catalysis and azomethine ylide chemistry, we have developed several types of novel catalytic system including Cu/Pd, Cu/Ir and PTC/Ir catalysis, which can convert readily-available azomethine ylides to various high-valued molecules such as unnatural α-amino acids, homoallylic amines and N-heterocycles. Compared with the traditional mono-catalysis, the synergistic catalyst system exhibits enhanced catalytic efficiency and chiral induction ability in many cases. In addition, we have demonstrated that these strategies could be applied in the construction of bioactive compounds and natural products.
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