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Enhanced Anticancer Cells Effects of Optimized Suspension Stable As₂O₃-Loaded Poly(lactic-co-glycolic acid) Nanocapsules

Corresponding Author

Xiaoli Song

[email protected]

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China, Tel.: 0086-0514-87975244; Fax: 0086-0514-87975244Search for more papers by this author

Juan You,

Juan You

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Chunlan Xu,

Chunlan Xu

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Aiping Zhu,

Aiping Zhu

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Caifeng Yan,

Caifeng Yan

Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China

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Rong Guo,

Corresponding Author

Rong Guo

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China, Tel.: 0086-0514-87975244; Fax: 0086-0514-87975244Search for more papers by this author

Xiaoli Song,

Corresponding Author

Xiaoli Song

[email protected]

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China, Tel.: 0086-0514-87975244; Fax: 0086-0514-87975244Search for more papers by this author

Juan You,

Juan You

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Chunlan Xu,

Chunlan Xu

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Aiping Zhu,

Aiping Zhu

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

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Caifeng Yan,

Caifeng Yan

Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China

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Rong Guo,

Corresponding Author

Rong Guo

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China, Tel.: 0086-0514-87975244; Fax: 0086-0514-87975244Search for more papers by this author

First published: 12 June 2015

https://doi.org/10.1002/cjoc.201500222

Citations: 4

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Abstract

This study is to prepare a nanosuspension based on poly(lactic-co-glycolic acid) (PLGA) for delivery, controlled release and enhanced anti-solid tumor effects of As₂O₃. As₂O₃-loaded PLGA nanocapsules (As₂O₃-PLGA NCs) were prepared by double emulsion-solvent evaporation method and were optimized by univariate analysis in combination with orthogonal experimental according to several factors. The optimized As₂O₃-PLGA NCs presented suitable physical stability, favorable size of (200.2±10.6) nm (PDI=0.117±0.008), spherical shape, and high encapsulation efficiency (92.48%±2.14%). The in vitro suspension stability of the NCs was excellent. The release of As₂O₃ from the NCs showed pH responsive release characteristics. The NCs can be efficiently taken up by SMMC-7721 cell and showed excellent antitumor efficacy against SMMC-7721 cell line. Then, As₂O₃-PLGA NCs could be considered as a promising formulation for the pH dependent release of As₂O₃ in cancer cells and enhance the anti-solid tumor effects of As₂O₃.

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Volume33, Issue7

July, 2015

Pages 777-784

Enhanced Anticancer Cells Effects of Optimized Suspension Stable As₂O₃-Loaded Poly(lactic-co-glycolic acid) Nanocapsules

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Enhanced Anticancer Cells Effects of Optimized Suspension Stable As₂O₃-Loaded Poly(lactic-co-glycolic acid) Nanocapsules