Impact of the Aliphatic Dicarboxylate Chain of Novel Dinuclear Palladium(II) Complexes: Synthesis and Biological Evaluation
Mingchang Zhu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorQiong Wu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorLei Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorHongyan Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorFuchun Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorYun Huang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorLei Wang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorQunzhi Shi
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorWanzhong Zhang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorMingchang Zhu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorQiong Wu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorLei Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorHongyan Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorFuchun Liu
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorYun Huang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorLei Wang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorQunzhi Shi
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorWanzhong Zhang
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China
Search for more papers by this authorAbstract
Five dinuclear palladium(II) complexes with HOOC(CH2)nCOOH (n=2–6) and 2,2′-bipyridine ligands were synthesigned by a reaction with K2PdCl4. To prepare such complexes with different aliphatic dicarboxylate chain lengths was in an attempt to correlate this length factor, which influences the biological activity of the complexes, with fluorescence spectra, DNA cleavage and cytotoxic activity. The results indicate that the complexes bind to fish sperm DNA (FS-DNA) in an intercalative mode via fluorescence spectra, and the five complexes show different cleavage of supercoiled DNA, and then a cytotoxicity assay of these dinuclear palladium(II) complexes on human tumor cell lines was performed. In most of the cell lines, complex 5 (n=6) and 4 (n=5) showed much higher cytotoxicity than cis-platin. On the other hand, complex 3 (n=4) was found to be moderately active, and complex 1 (n=2), complex 2 (n=3) were found only marginally cytotoxic. Implications of these findings were discussed from a structure-activity relationship.
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