Volume 25, Issue 11 pp. 1728-1731
Full Paper

Alkaloids from Fritillaria Hupehensis

Yong-Hui ZHANG

Yong-Hui ZHANG

Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

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Xi-Liang YANG

Xi-Liang YANG

Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

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Xue-Feng ZHOU

Xue-Feng ZHOU

Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

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Han-Li RUAN

Han-Li RUAN

Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

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Hui-Fang PI

Hui-Fang PI

Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

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Ji-Zhou WU

Ji-Zhou WU

Tel.: 0086-027-83692739; Fax: 0086-027-83692739

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Han-Dong SUN

Han-Dong SUN

Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China

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First published: 13 November 2007
Citations: 6

Abstract

Phytochemical investigation of the bulbs of Fritillaria hupehensis resulted in the isolation and structural elucidation of a new highly conjugated alkaloid of veratramine type identified as 3β,23β-dihydroxy-7,12(14)-dien-5α-veratramin-6-one (1), together with two known alkaloids, ebeinine (2) and zhebeinine (3), which were isolated for the first time from F. hupehensis. The structures of alkaloids 13 were established by extensive 1D and 2D NMR spectral analyses.

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