Full Paper
Kinetic Resolution of 2-Chloro-1-(3,4-dichlorophenyl)ethanol by Lipase-Catalyzed Transesterification
First published: 13 November 2007
Abstract
Kinetic resolution of racemic 2-chloro-1-(3,4-dichlorophenyl)ethanol was performed by free Alcaligene sp. lipase-catalyzed irreversible transesterification affording the (R)-isomer with ≧ 95% ee and the (S)-isomer with ≧ 90% ee. The activity of lipase Alcaligene sp. strongly depends on the basicity of the reaction system, and an organic base such as triethylamine can enhance the activity of the lipase and enantioselectivity markedly.
