Volume 42, Issue 21
Other Subjects

ChemInform Abstract: Synthesis and in vitro Antimycobacterial Activity of 8-OCH3 Ciprofloxacin Methylene and Ethylene Isatin Derivatives.

Lian-Shun Feng

Lian-Shun Feng

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Ming-Liang Liu

Ming-Liang Liu

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Shu Zhang

Shu Zhang

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Yun Chai

Yun Chai

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Bo Wang

Bo Wang

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Yi-Bin Zhang

Yi-Bin Zhang

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Kai Lv

Kai Lv

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Yan Guan

Yan Guan

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Hui-Yuan Guo

Hui-Yuan Guo

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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Chun-Ling Xiao

Chun-Ling Xiao

Inst. Med. Biotechnol., Chin. Acad. Med. Sci., Beijing 100050, Peop. Rep. China

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First published: 28 April 2011

Abstract

A series of novel 8-OMe ciprofloxacin methylene and ethylene isatin derivatives (I) with remarkable improvement in lipophilicity are synthesized and evaluated for their in vitro activity against some mycobacteria.

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