Catheterization and Cardiovascular Interventions

ORIGINAL ARTICLE - CLINICAL SCIENCE

Association Between Triglyceride-Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage Occlusion: A Retrospective Observational Study

Xiao-hai Jiang

orcid.org/0009-0004-6399-6244

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Mei-xiang Wang,

Mei-xiang Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Run-zhong Wang,

Run-zhong Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Yawen Sheng,

Yawen Sheng

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Jian Wang,

Jian Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Zhong-bao Ruan,

Corresponding Author

Zhong-bao Ruan

[email protected]

orcid.org/0000-0003-0607-0010

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

Correspondence: Zhong-bao Ruan ([email protected])

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Li Zhu,

Li Zhu

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Xiao-hai Jiang,

Xiao-hai Jiang

orcid.org/0009-0004-6399-6244

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Mei-xiang Wang,

Mei-xiang Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Run-zhong Wang,

Run-zhong Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Yawen Sheng,

Yawen Sheng

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Jian Wang,

Jian Wang

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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Zhong-bao Ruan,

Corresponding Author

Zhong-bao Ruan

[email protected]

orcid.org/0000-0003-0607-0010

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

Correspondence: Zhong-bao Ruan ([email protected])

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Li Zhu,

Li Zhu

Department of Cardiology, Taizhou School of Clinical Medicine, the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China

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First published: 24 April 2025

https://doi.org/10.1002/ccd.31556

All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Xiao-hai Jiang and Mei-xiang Wang contributed equally to this study.

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ABSTRACT

Background

The triglyceride-glucose (TyG) index, a biomarker for insulin resistance, has been shown to be associated with cardiovascular diseases. However, its association with delayed device endothelialization after left atrial appendage occlusion (LAAO) has not yet been explored.

Methods

This retrospective study included 594 patients with non-valvular atrial fibrillation (NVAF) who underwent LAAO with the Watchman2.5 device at the Electrophysiology Center of Taizhou People's Hospital, Nanjing Medical University. Postoperative follow-up was performed at 3 months using Contrast-Enhanced Computed Tomography Angiography (CCTA). Patients were grouped based on quartiles of the TyG index. Logistic regression analysis and restricted cubic spline (RCS) regression models were used to evaluate the association between the TyG index and incomplete device endothelialization (IDE) postprocedure.

Results

The TyG index was divided into four groups based on quartiles, with Group 1 (TyG index ≤ 8.17) serving as the reference. In Groups 3 (8.32 < TyG index ≤ 8.50) and 4 (TyG index > 8.50), the TyG index was identified as an independent risk factor for IDE postprocedure. The RCS model confirmed a significant linear relationship between the TyG index and IDE postprocedure. Furthermore, the association between the TyG index and IDE was consistent across different subgroups.

Conclusion

A higher TyG index was significantly associated with IDE after LAAO, suggesting that it could serve as a simple, cost-effective biomarker for predicting the risk of IDE in this population.

Conflicts of Interest

The authors declare no conflicts of interest.

Open Research

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Volume106, Issue1

July 1, 2025

Pages 384-395

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Association Between Triglyceride-Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage Occlusion: A Retrospective Observational Study

ABSTRACT

Background

Methods

Results

Conclusion

Conflicts of Interest

Open Research

Data Availability Statement

References

References

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Association Between Triglyceride-Glucose Index and Incomplete Device Endothelialization After Left Atrial Appendage Occlusion: A Retrospective Observational Study

ABSTRACT

Background

Methods

Results

Conclusion

Conflicts of Interest

Open Research

Data Availability Statement

References

References

Related

Information