Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves
Aternoskaires S. R. da Silva
Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970 Rio Verde, GO, Brazil
Search for more papers by this authorCassia C. Fernandes
Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970 Rio Verde, GO, Brazil
Search for more papers by this authorDaiane A. dos Santos
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorMarya C. M. Mazza
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorJackson B. A. Silva
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901 Ribeirão Preto, Brazil
Search for more papers by this authorLizandra G. Magalhães
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorRegina H. Pires
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorCorresponding Author
Mayker L. D. Miranda
lnstituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro, Campus Uberlândia, Centro, CEP, MG-38411-104 Uberlândia, Brazil
Search for more papers by this authorCorresponding Author
Antônio E. M. Crotti
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901 Ribeirão Preto, Brazil
Search for more papers by this authorAternoskaires S. R. da Silva
Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970 Rio Verde, GO, Brazil
Search for more papers by this authorCassia C. Fernandes
Instituto Federal de Educação, Ciência e Tecnologia Goiano, Campus Rio Verde, 75.901-970 Rio Verde, GO, Brazil
Search for more papers by this authorDaiane A. dos Santos
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorMarya C. M. Mazza
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorJackson B. A. Silva
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901 Ribeirão Preto, Brazil
Search for more papers by this authorLizandra G. Magalhães
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorRegina H. Pires
Universidade de Franca, CEP, 14404-600 Franca, SP, Brazil
Search for more papers by this authorCorresponding Author
Mayker L. D. Miranda
lnstituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro, Campus Uberlândia, Centro, CEP, MG-38411-104 Uberlândia, Brazil
Search for more papers by this authorCorresponding Author
Antônio E. M. Crotti
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, SP-14040-901 Ribeirão Preto, Brazil
Search for more papers by this authorAbstract
This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils (VOs) of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93 %), β-caryophyllene (19.90 %), and caryophyllene oxide (12.69 %), whereas (E)-cinnamaldehyde (60.11 %), cinnamyl acetate (20.90 %) and cis-2-methoxycinnamic acid (10.37 %) were predominant in CC. SM (IC50=21.45 μg/mL) and CC (IC50=23.27 μg/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 μg/mL. While the three SM and CC blends were not more active than the VOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 μg/mL, which is very similar to the IC50 of amphotericin B (positive control).
Graphical Abstract
Conflict of Interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are openly available in ChemRxiv at https://doi.org/10.26434/chemrxiv-2024-xv7db.
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