Synthesis and surface modification of sunflower oil-based non-isocyanate polyurethane: Physicochemical and antibacterial properties
María del Pilar Maya
Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Medellín, Colombia
Contribution: Conceptualization (lead), Formal analysis (lead), Investigation (lead), Methodology (lead), Validation (equal), Writing - original draft (lead), Writing - review & editing (supporting)
Search for more papers by this authorSusana Torres
Cellular and Molecular Biology Unit; Corporación Para Investigaciones Biológicas (CIB); School of Microbiology. Universidad De Antioquia, Medellín, Colombia
Contribution: Formal analysis (equal), Investigation (supporting), Validation (equal), Writing - original draft (supporting)
Search for more papers by this authorCorresponding Author
Carmiña Gartner
Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Medellín, Colombia
Correspondence
Carmiña Gartner, Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Calle 70 N° 52-21, Medellín 05001000, Colombia.
Email: [email protected]
Contribution: Conceptualization (lead), Formal analysis (lead), Funding acquisition (lead), Investigation (lead), Project administration (lead), Resources (lead), Supervision (equal), Validation (equal), Writing - original draft (equal), Writing - review & editing (lead)
Search for more papers by this authorMaría del Pilar Maya
Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Medellín, Colombia
Contribution: Conceptualization (lead), Formal analysis (lead), Investigation (lead), Methodology (lead), Validation (equal), Writing - original draft (lead), Writing - review & editing (supporting)
Search for more papers by this authorSusana Torres
Cellular and Molecular Biology Unit; Corporación Para Investigaciones Biológicas (CIB); School of Microbiology. Universidad De Antioquia, Medellín, Colombia
Contribution: Formal analysis (equal), Investigation (supporting), Validation (equal), Writing - original draft (supporting)
Search for more papers by this authorCorresponding Author
Carmiña Gartner
Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Medellín, Colombia
Correspondence
Carmiña Gartner, Grupo De Investigación Ciencia De Los Materiales, Sede de Investigación Universitaria, SIU, Universidad De Antioquia, Calle 70 N° 52-21, Medellín 05001000, Colombia.
Email: [email protected]
Contribution: Conceptualization (lead), Formal analysis (lead), Funding acquisition (lead), Investigation (lead), Project administration (lead), Resources (lead), Supervision (equal), Validation (equal), Writing - original draft (equal), Writing - review & editing (lead)
Search for more papers by this authorAbstract
In this work, non-isocyanate polyurethane (NIPU) films are synthesized from sunflower oil (SFO) with the object of using a renewable resource and establishing a nonpolluting process. SFO also has the advantage of having a higher level of unsaturation than other commercial oils, which provides more reactive sites to be chemically modified. This feature enables a higher degree of conversion to the two monomers, cyclocarbonate, and polyamine-polyol. NIPU is obtained from their mixture and further crosslinking at 90°C allows the films with suitable mechanical properties to be used in biomedical applications. However, NIPU does not show antibacterial activity, so the surface must be modified. Two methods are used: layer-by-layer coating of alginate-chitosan, and immersion in tea tree oil (TTO), previously activating the surface with acrylic acid (AANIPU). Surface modifications are confirmed by increased hydrophilicity, thermochemical changes, and a drop in mechanical performance. TTO on NIPU films inhibits bacterial growth against S. aureus and E. Coli. NIPU and AANIPU can be accepted as noncytotoxic, while incorporation of the two agents can produce cytotoxicity. No previous reports of such modifications have been found on NIPU films, which appear as promising alternatives for biomedical applications.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| app55181-sup-0001-FgureS1.pngPNG image, 70.4 KB | Figure S1: FTIR spectra of modifying agents: (a) Acrylic acid. (b) Chitosan. (c) Sodium alginate. (d) Tea tree oil (TTO). |
| app55181-sup-0002-FgureS2.pngPNG image, 328.5 KB | Figure S2: Results of glass transition measurements by DSC of NIPU precursors and films before and after different surface treatments. |
| app55181-sup-0003-FgureS3.pngPNG image, 687.1 KB | Figure S3: TGA results for SFO-based precursors, CSFO and PAPO, for the NIPU film and after the treatments with acrylic acid, chitosan-alginate, and tea tree oil. |
| app55181-sup-0004-FgureS4.pngPNG image, 26.7 KB | Figure S4: Comparison of strain–stress curves for unmodified NIPU and the surface modified samples: AANIPU, TTONIPU and AL-CSNIPU. |
| app55181-sup-0005-TableS1.docxWord 2007 document , 55.9 KB | Table S1: N1s curve fitting results of XPS for different NIPU films. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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