Temperature stimuli-responsive nanoparticles from chitosan-graft-poly(N-vinylcaprolactam) as a drug delivery system
Corresponding Author
Daniel Fernández-Quiroz
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Correspondence to: D. Fernández-Quiroz ([email protected]); M. Pedroza-Montero ([email protected])Search for more papers by this authorJorge Loya-Duarte
Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorErika Silva-Campa
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorWaldo Argüelles-Monal
Centro de Investigación en Alimentación y Desarrollo, Grupo de Investigación en Biopolímeros, Hermosillo, Sonora 83304, Mexico
Search for more papers by this authorAndre-í Sarabia-Sainz
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorArmando Lucero-Acuña
Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorTeresa del Castillo-Castro
Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorJulio San Román
Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Madrid 28006, Spain
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid 28029, Spain
Search for more papers by this authorJaime Lizardi-Mendoza
Centro de Investigación en Alimentación y Desarrollo, Grupo de Investigación en Biopolímeros, Hermosillo, Sonora 83304, Mexico
Search for more papers by this authorAlexel J. Burgara-Estrella
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorBeatriz Castaneda
Departamento de Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorDiego Soto-Puebla
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorCorresponding Author
Martín Pedroza-Montero
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Correspondence to: D. Fernández-Quiroz ([email protected]); M. Pedroza-Montero ([email protected])Search for more papers by this authorCorresponding Author
Daniel Fernández-Quiroz
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Correspondence to: D. Fernández-Quiroz ([email protected]); M. Pedroza-Montero ([email protected])Search for more papers by this authorJorge Loya-Duarte
Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorErika Silva-Campa
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorWaldo Argüelles-Monal
Centro de Investigación en Alimentación y Desarrollo, Grupo de Investigación en Biopolímeros, Hermosillo, Sonora 83304, Mexico
Search for more papers by this authorAndre-í Sarabia-Sainz
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorArmando Lucero-Acuña
Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorTeresa del Castillo-Castro
Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorJulio San Román
Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Madrid 28006, Spain
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid 28029, Spain
Search for more papers by this authorJaime Lizardi-Mendoza
Centro de Investigación en Alimentación y Desarrollo, Grupo de Investigación en Biopolímeros, Hermosillo, Sonora 83304, Mexico
Search for more papers by this authorAlexel J. Burgara-Estrella
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorBeatriz Castaneda
Departamento de Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorDiego Soto-Puebla
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Search for more papers by this authorCorresponding Author
Martín Pedroza-Montero
Departamento de Investigación en Física, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico
Correspondence to: D. Fernández-Quiroz ([email protected]); M. Pedroza-Montero ([email protected])Search for more papers by this authorABSTRACT
This work describes the preparation of thermosensitive chitosan-graft-poly(N-vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N-vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug-association parameters, and the drug-loaded nanoparticles exhibited dose-dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti-cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47831.
Supporting Information
| Filename | Description |
|---|---|
| app47831-sup-0001-Supinfo.docxWord 2007 document , 2.8 MB | Figure S1. SEM images of Cs-g-PVCL-190 nanoparticles Figure S2. FTIR spectra of free doxorubicin and DOX-loaded nanoparticles. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Duncan, R.; Gaspar, R. Mol. Pharmaceutics. 2011, 8, 2101.
- 2Talelli, M.; Duro-Castaño, A.; Rodríguez-Escalona, G.; Vicent, M. J. In Smart Polymers and Their Applications; M. R. Aguilar; J. San Román, Eds., Woodhead Publishing: Cambridge, UK, 2014. p. 327.
- 3Wagner, A. M.; Spencer, D. S.; Peppas, N. A. J. Appl. Polym. Sci. 2018, 135, 46154.
- 4Bawa, P.; Pillay, V.; Choonara, Y. E.; du Toit, L. C. Biomed. Mater. 2009, 4, 022001.
- 5Hoogenboom, R. In Smart Polymers and Their Applications; M. R. Aguilar; J. San Román, Eds., Woodhead Publishing: Cambridge, UK, 2014. p. 15.
10.1533/9780857097026.1.15 Google Scholar
- 6Recillas, M.; Silva, L. L.; Peniche, C.; Goycoolea, F. M.; Rinaudo, M.; Argüelles-Monal, W. M. Biomacromolecules. 2009, 10, 1633.
- 7Menon, J. U.; Nguyen, D. X.; Nguyen, K. T. In Handbook of Nanoparticles; M. Aliofkhazraei, Ed., Springer International Publishing: New York, 2016. p. 347.
10.1007/978-3-319-15338-4_19 Google Scholar
- 8Shao, P.; Wang, B.; Wang, Y.; Li, J.; Zhang, Y.; Shao, P.; Wang, B.; Wang, Y.; Li, J.; Zhang, Y. J. Nanomater. 2011, 2011, 389640.
- 9Argüelles-Monal, W.; Recillas-Mota, M.; Fernández-Quiroz, D. In Biological Activities and Application of Marine Polysaccharides; E. Shalaby, Ed., InTech: London, 2017. p. 279.
- 10Rejinold, N. S.; Chennazhi, K. P.; Nair, S. V.; Tamura, H.; Jayakumar, R. Carbohydr. Polym. 2011, 83, 776.
- 11Rejinold, N. S.; Thomas, R. G.; Muthiah, M.; Chennazhi, K. P.; Park, I.-K.; Jeong, Y. Y.; Manzoor, K.; Jayakumar, R. RSC Adv. 2014, 4, 39408.
- 12Sanoj Rejinold, N.; Muthunarayanan, M.; Divyarani, V. V.; Sreerekha, P. R.; Chennazhi, K. P.; Nair, S. V.; Tamura, H.; Jayakumar, R. J. Colloid Interface Sci. 2011, 360, 39.
- 13Sanoj Rejinold, N.; Thomas, R. G.; Muthiah, M.; Chennazhi, K. P.; Manzoor, K.; Park, I.-K.; Jeong, Y. Y.; Jayakumar, R. Int. J. Biol. Macromol. 2015, 74, 249.
- 14Rejinold, N. S.; Thomas, R. G.; Muthiah, M.; Lee, H. J.; Jeong, Y. Y.; Park, I.-K.; Jayakumar, R. J. Biomed. Nanotechnol. 2016, 12, 43.
- 15Prabaharan, M.; Grailer, J. J.; Steeber, D. A.; Gong, S. Macromol. Biosci. 2008, 8, 843.
- 16Indulekha, S.; Arunkumar, P.; Bahadur, D.; Srivastava, R. Mater. Sci. Eng. C. 2016, 62, 113.
- 17Fernández-Quiroz, D.; González-Gómez, Á.; Lizardi-Mendoza, J.; Vázquez-Lasa, B.; Goycoolea, F. M.; Román, J. S.; Argüelles-Monal, W. M. Colloid Polym. Sci. 2016, 294, 555.
- 18Fernández-Quiroz, D.; González-Gómez, Á.; Lizardi-Mendoza, J.; Vázquez-Lasa, B.; Goycoolea, F. M.; San Román, J.; Argüelles-Monal, W. M. Carbohydr. Polym. 2015, 134, 92.
- 19Cruz, A.; García-Uriostegui, L.; Ortega, A.; Isoshima, T.; Burillo, G. Carbohydr. Polym. 2017, 155, 303.
- 20Calvo, P.; Remuñán-López, C.; Vila-Jato, J. L.; Alonso, M. J. J. Appl. Polym. Sci. 1997, 63, 125.
- 21Sreekumar, S.; Goycoolea, F. M.; Moerschbacher, B. M.; Rivera-Rodriguez, G. R. Sci. Rep. 2018, 8, 4695.
- 22Fernández-Gutiérrez, M.; Bossio, O.; Gómez-Mascaraque, L. G.; Vázquez-Lasa, B.; Román, J. S. Macromol. Chem. Phys. 2015, 216, 1321.
- 23Goycoolea, F. M.; Lollo, G.; Remuñán-López, C.; Quaglia, F.; Alonso, M. J. Biomacromolecules. 2009, 10, 1736.
- 24Luque-Alcaraz, A. G.; Lizardi-Mendoza, J.; Goycoolea, F. M.; Higuera-Ciapara, I.; Argüelles-Monal, W. RSC Adv. 2016, 6, 59250.
- 25Peniche, C.; Argüelles-Monal, W.; Peniche, H.; Acosta, N. Macromol. Biosci. 2003, 3, 511.
- 26Socrates, G. Infrared and Raman Characteristic Group Frequencies: Tables and Charts. 3rd ed.; John Wiley & Sons: New York, 2001.
- 27Pan, H.; Marsh, J. N.; Christenson, E. T.; Soman, N. R.; Ivashyna, O.; Lanza, G. M.; Schlesinger, P. H.; Wickline, S. A. In Methods in Enzymology; N. Düzgüneş, Ed.; Vol. 508, Academic Press: Cambridge, MA, 2012. p. 17.
- 28Gumustas, M.; Sengel-Turk, C. T.; Gumustas, A.; Ozkan, S. A.; Uslu, B. In In Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics; A. M. Grumezescu, Ed., Elsevier: Amsterdam, Netherlands, 2017. p. 67.
- 29Lazzari, S.; Moscatelli, D.; Codari, F.; Salmona, M.; Morbidelli, M.; Diomede, L. J Nanopart. Res. 2012, 14, 920.
- 30López-León, T.; Carvalho, E. L. S.; Seijo, B.; Ortega-Vinuesa, J. L.; Bastos-González, D. J. Colloid Interface Sci. 2005, 283, 344.
- 31Meeussen, F.; Nies, E.; Berghmans, H.; Verbrugghe, S.; Goethals, E.; Du Prez, F. Polymer. 2000, 41, 8597.
- 32Beija, M.; Marty, J.-D.; Destarac, M. Chem. Commun. 2011, 47, 2826.
- 33Cheng, H.; Shen, L.; Wu, C. Macromolecules. 2006, 39, 2325.
- 34Mohammed, M.; Syeda, J.; Wasan, K.; Wasan, E.; Mohammed, M. A.; Syeda, J. T. M.; Wasan, K. M.; Wasan, E. K. Pharmaceutics. 2017, 9, 53.
- 35Boyer, C.; Whittaker, M. R.; Luzon, M.; Davis, T. P. Macromolecules. 2009, 42, 6917.
- 36Raula, J.; Shan, J.; Nuopponen, M.; Niskanen, A.; Jiang, H.; Kauppinen, E. I.; Tenhu, H. Langmuir. 2003, 19, 3499.
- 37Yang, M.; Ding, Y.; Zhang, L.; Qian, X.; Jiang, X.; Liu, B. J. Biomed. Mater. Res. Part A. 2007, 81A, 847.
- 38Gibson, I. M.; O'Reilly, K. R. Chem. Soc. Rev. 2013, 42, 7204.
- 39Ramalingam, V.; Varunkumar, K.; Ravikumar, V.; Rajaram, R. Sci. Rep. 2018, 8, 3815.
- 40Soares, P. I. P.; Sousa, A. I.; Silva, J. C.; Ferreira, I. M. M.; Novo, C. M. M.; Borges, J. P. Carbohydr. Polym. 2016, 147, 304.
- 41Rao, W.; Wang, H.; Han, J.; Zhao, S.; Dumbleton, J.; Agarwal, P.; Zhang, W.; Zhao, G.; Yu, J.; Zynger, D. L.; Lu, X.; He, X. ACS Nano. 2015, 9, 5725.
- 42Mitra, S.; Gaur, U.; Ghosh, P. C.; Maitra, A. N. J. Controlled Release. 2001, 74, 317.
- 43Chandra, S.; Dietrich, S.; Lang, H.; Bahadur, D. J. Mater. Chem. 2011, 21, 5729.
- 44Lucero-Acuña, A.; Guzmán, R. Int. J. Pharmaceutics. 2015, 494, 249.
- 45Fredenberg, S.; Wahlgren, M.; Reslow, M.; Axelsson, A. Int. J. Pharmaceutics. 2011, 415, 34.
- 46Gutiérrez-Valenzuela, C. A.; Esquivel, R.; Guerrero-Germán, P.; Zavala-Rivera, P.; Rodríguez-Figueroa, J. C.; Guzmán-Z, R.; Lucero-Acuña, A. RSC Adv. 2018, 8, 414.
- 47Crank, J. The Mathematics of Diffusion. 2nd ed.; Clarendon Press: Oxford, Great Britain, 1975.
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