Visible-Light-Mediated Metal-Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)−H Alkanes
Dr. Jing Hou
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorAloysius Ee
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorHui Cao
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorHan-Wee Ong
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorJin-Hui Xu
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorCorresponding Author
Dr. Jie Wu
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorDr. Jing Hou
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorAloysius Ee
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorHui Cao
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorHan-Wee Ong
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorJin-Hui Xu
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorCorresponding Author
Dr. Jie Wu
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Republic of Singapore
Search for more papers by this authorGraphical Abstract
Photocarboxylation: Visible-light-promoted metal-free difunctionalization of alkenes using CO2 and readily available Si−H and C(sp3)−H reagents has been realized by the merging of photoredox and hydrogen-atom-transfer catalysis. A variety of valuable compounds, such as β-silacarboxylic acids and acids bearing a γ-heteroatom (e.g., N, O, S) can be directly accessed from simple alkenes in a redox-neutral fashion.
Abstract
Catalytic alkene difunctionalization via Si−H and C−H activations represents an ideal atom- and step-economic pathway for quick assembly of molecular complexity. We herein developed a visible-light-promoted metal-free difunctionalization of alkenes using abundant CO2 and readily available Si−H and C(sp3)−H bonds as feedstocks. Through the merger of photoredox and hydrogen-atom-transfer catalysis, a variety of value-added compounds, such as β-silacarboxylic acids and acids bearing a γ-heteroatom (e.g., N, O, S) could be directly accessed from simple alkenes in a redox-neutral fashion.
Supporting Information
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