Chemoselective Pd-Catalyzed C-TeCF3 Coupling of Aryl Iodides
Theresa Sperger
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorSinem Guven
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. Franziska Schoenebeck
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorTheresa Sperger
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorSinem Guven
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. Franziska Schoenebeck
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Search for more papers by this authorGraphical Abstract
Te time: The first direct catalytic method for the formation of C(sp2)−TeCF3 bonds has been developed. It relies on a Pd/Xantphos catalytic system and allows for the trifluoromethylellurolation of aryl iodides. Computational and experimental mechanistic analyses shed light on the privileged activity of Xantphos in this transformation.
Abstract
While the TeCF3 moiety features promising properties and potential in a range of applications, no direct synthetic method exists for its incorporation into aromatic scaffolds. This report features the first direct catalytic method for the formation of C(sp2)−TeCF3 bonds. The method relies on a Pd/Xantphos catalytic system and allows for the trifluoromethyltellurolation of aryl iodides. Our computational and experimental mechanistic analyses shed light on the privileged activity of Xantphos in this transformation.
Supporting Information
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