Volume 55, Issue 38 pp. 11340-11342
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Decarboxylative Alkyl–Alkyl Cross-Coupling Reactions

Mikhail O. Konev

Mikhail O. Konev

Department of Chemistry, University of California, Irvine, Irvine, CA, 92697 USA

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Prof. Dr. Elizabeth R. Jarvo

Corresponding Author

Prof. Dr. Elizabeth R. Jarvo

Department of Chemistry, University of California, Irvine, Irvine, CA, 92697 USA

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First published: 15 July 2016
Citations: 56

Graphical Abstract

Alkyl with alkyl: A significant development in alkyl–alkyl cross-coupling reactions, namely the nickel-catalyzed decarboxylative Negishi coupling of N-hydroxyphthalimide esters, was recently reported by Baran and co-workers. This method enables the synthesis of various highly functionalized compounds, including natural product derivatives.

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