High-Resolution Crystal Structure of a Silver(I)–RNA Hybrid Duplex Containing Watson–Crick-like CSilver(I)C Metallo-Base Pairs
Corresponding Author
Dr. Jiro Kondo
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Graduate School of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)Search for more papers by this authorYoshinari Tada
Graduate School of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Search for more papers by this authorDr. Takenori Dairaku
Laboratory of Molecular Transformation, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan)
Search for more papers by this authorDr. Hisao Saneyoshi
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorDr. Itaru Okamoto
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorProf. Yoshiyuki Tanaka
Laboratory of Molecular Transformation, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan)
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, 770-8514 Tokushima (Japan)
Search for more papers by this authorProf. Akira Ono
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorCorresponding Author
Dr. Jiro Kondo
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Graduate School of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)Search for more papers by this authorYoshinari Tada
Graduate School of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
Search for more papers by this authorDr. Takenori Dairaku
Laboratory of Molecular Transformation, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan)
Search for more papers by this authorDr. Hisao Saneyoshi
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorDr. Itaru Okamoto
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorProf. Yoshiyuki Tanaka
Laboratory of Molecular Transformation, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578 (Japan)
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, 770-8514 Tokushima (Japan)
Search for more papers by this authorProf. Akira Ono
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686 (Japan)
Search for more papers by this authorGraphical Abstract
The high-resolution structures of CAgIC base pairs in A-form RNA duplexes have been solved. Structural information on the present metallo-base pair together with the previously reported THgIIT base pair widely open the possibility of structure-based design of nucleic-acid-based nanodevices containing the natural metallo-base pairs.
Abstract
Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THgIIT base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases CAgIC formed in an RNA duplex. One AgI occupies the center between two cytosines and forms a CAgIC base pair through N3AgIN3 linear coordination. The CAgIC base pair formation does not disturb the standard A-form conformation of RNA. Since the CAgIC base pair is structurally similar to the canonical Watson–Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices.
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