Volume 54, Issue 45 pp. 13166-13168
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Arrestin-Bound Rhodopsin: A Molecular Structure and its Impact on the Development of Biased GPCR Ligands

Dr. Dorothee Möller

Dr. Dorothee Möller

Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen (Germany)

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Prof. Dr. Peter Gmeiner

Corresponding Author

Prof. Dr. Peter Gmeiner

Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen (Germany)

Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen (Germany)Search for more papers by this author
First published: 11 September 2015
Citations: 2

Graphical Abstract

Freeze, you’re under arrest: Serial femtosecond crystallography was used to solve the first high-resolution structure of the G-protein-coupled receptor rhodopsin bound to the adaptor protein arrestin. This template may be useful for the structure-based design of functionally selective drugs.

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