Instantaneous Hydrolysis of Nerve-Agent Simulants with a Six-Connected Zirconium-Based Metal–Organic Framework†
Dr. Su-Young Moon
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
These authors contributed equally to this work.
Search for more papers by this authorDr. Yangyang Liu
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Joseph T. Hupp
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)Search for more papers by this authorCorresponding Author
Prof. Omar K. Farha
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)Search for more papers by this authorDr. Su-Young Moon
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
These authors contributed equally to this work.
Search for more papers by this authorDr. Yangyang Liu
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Prof. Joseph T. Hupp
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)Search for more papers by this authorCorresponding Author
Prof. Omar K. Farha
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)
Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)
Department of chemistry Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA)Search for more papers by this authorWe gratefully acknowledge DTRA for financial support (grant HDTRA-1-10-0023). This work made use of the J. B. Cohen X-Ray Diffraction Facility supported by the MRSEC program of the National Science Foundation (DMR-1121262) at the Materials Research Center of Northwestern University.
Graphical Abstract
Detox, faster than fast: Chemical-warfare agents, including nerve agents, are a threat to humans. A six-connected zirconium metal–organic framework (MOF) can hydrolyze a nerve-agent simulant within 30 s which is faster than any other catalyst reported. It is a promising material for protective equipment as well as the elimination of large stores of nerve agents.
Abstract
A nerve-agent simulant based on a phosphate ester is hydrolyzed using a MOF-based catalyst. Suspensions of MOF-808 (6-connected), a material featuring 6-connected zirconium nodes, display the highest hydrolysis rates among all MOFs that have been reported to date. A plug-flow reactor was also prepared with MOF-808 (6-connected) as the active layer. Deployed in a simple filtration scheme, the reactor displayed high hydrolysis efficiency and reusability.
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