Volume 54, Issue 11 pp. 3449-3464
Review

Organic Synthesis: March of the Machines

Prof. Steven V. Ley

Corresponding Author

Prof. Steven V. Ley

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)Search for more papers by this author
Daniel E. Fitzpatrick

Daniel E. Fitzpatrick

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

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Dr. Richard. J. Ingham

Dr. Richard. J. Ingham

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

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Dr. Rebecca M. Myers

Dr. Rebecca M. Myers

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

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First published: 13 January 2015
Citations: 410

Graphical Abstract

Transforming chemistry: New technologies and machines have found use as methods for changing the way we work, addressing the resource-based issues encountered in research laboratories by enabling chemists to adopt a more holistic systems approach in their work. This Review focuses on the concepts, procedures, and methods that have far-reaching implications in the chemistry world.

Abstract

Organic synthesis is changing; in a world where budgets are constrained and the environmental impacts of practice are scrutinized, it is increasingly recognized that the efficient use of human resource is just as important as material use. New technologies and machines have found use as methods for transforming the way we work, addressing these issues encountered in research laboratories by enabling chemists to adopt a more holistic systems approach in their work. Modern developments in this area promote a multi-disciplinary approach and work is more efficient as a result. This Review focuses on the concepts, procedures and methods that have far-reaching implications in the chemistry world. Technologies have been grouped as topics of opportunity and their recent applications in innovative research laboratories are described.

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