Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery†
Yincheng Chang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
These authors contributed equally.
Search for more papers by this authorKui Yang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
These authors contributed equally.
Search for more papers by this authorPeng Wei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorSisi Huang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Yuxin Pei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)Search for more papers by this authorWei Zhao
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhichao Pei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)Search for more papers by this authorYincheng Chang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
These authors contributed equally.
Search for more papers by this authorKui Yang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
These authors contributed equally.
Search for more papers by this authorPeng Wei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorSisi Huang
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Yuxin Pei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)Search for more papers by this authorWei Zhao
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhichao Pei
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)
College of Science, Northwest A&F University, Yangling, Shaanxi 712100 (P.R. China)Search for more papers by this authorThis research work was supported by the National Natural Science Foundation of China (NSFC 21174113 and NSFC 31270861). We thank Yihan Pei (Clare College, Cambridge) for language help.
Graphical Abstract
Simultaneous delivery of an anticancer drug and siRNA was achieved with cationic vesicles self-assembled from a novel ferrocenium-capped amphiphilic pillar[5]arene. These systems exhibit low cytotoxicity to healthy cells and are redox-responsive in the presence of a reductant/oxidant.
Abstract
A novel ferrocenium capped amphiphilic pillar[5]arene (FCAP) was synthesized and self-assembled to cationic vesicles in aqueous solution. The cationic vesicles, displaying low cytotoxicity and significant redox-responsive behavior due to the redox equilibrium between ferrocenium cations and ferrocenyl groups, allow building an ideal glutathione (GSH)-responsive drug/siRNA co-delivery system for rapid drug release and gene transfection in cancer cells in which higher GSH concentration exists. This is the first report of redox-responsive vesicles assembled from pillararenes for drug/siRNA co-delivery; besides enhancing the bioavailability of drugs for cancer cells and reducing the adverse side effects for normal cells, these systems can also overcome the drug resistance of cancer cells. This work presents a good example of rational design for an effective stimuli-responsive drug/siRNA co-delivery system.
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