Au@Pt Nanoparticle Encapsulated Target-Responsive Hydrogel with Volumetric Bar-Chart Chip Readout for Quantitative Point-of-Care Testing†
Prof. Zhi Zhu
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorZhichao Guan
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorShasha Jia
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorZhichao Lei
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorDr. Shuichao Lin
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorHuimin Zhang
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorYanli Ma
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorProf. Zhong-Qun Tian
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorCorresponding Author
Prof. Chaoyong James Yang
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)Search for more papers by this authorProf. Zhi Zhu
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorZhichao Guan
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorShasha Jia
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
These authors contributed equally to this work.
Search for more papers by this authorZhichao Lei
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorDr. Shuichao Lin
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorHuimin Zhang
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorYanli Ma
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorProf. Zhong-Qun Tian
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
Search for more papers by this authorCorresponding Author
Prof. Chaoyong James Yang
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)
State Key Laboratory of Physical Chemistry of Solid Surfaces the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)Search for more papers by this authorThis work was supported by the National Basic Research Program of China (2010CB732402, 2013CB933703), the National Science Foundation of China (91313302, 21205100, 21275122), and the National Science Foundation for Distinguished Young Scholars of China (21325522).
Graphical Abstract
Seeing is believing: A simple and general quantitative method has been developed by integration of target-responsive hydrogels, Au core/Pt shell nanoparticles to catalyze the decomposition of H2O2 to O2, and a volumetric bar-chart chip for a visual quantitative readout. A wide range of targets can be detected without any external electronic devices, as demonstrated for cocaine, with a detection limit of 0.33 μM in urine.
Abstract
Point-of-care testing (POCT) with the advantages of speed, simplicity, portability, and low cost is critical for the measurement of analytes in a variety of environments where access to laboratory infrastructure is lacking. While qualitative POCTs are widely available, quantitative POCTs present significant challenges. Here we describe a novel method that integrates an Au core/Pt shell nanoparticle (Au@PtNP) encapsulated target-responsive hydrogel with a volumetric bar-chart chip (V-Chip) for quantitative POCT. Upon target introduction, the hydrogel immediately dissolves and releases Au@PtNPs, which can efficiently catalyze the decomposition of H2O2 to generate a large volume of O2 to move of an ink bar in the V-Chip. The concentration of the target introduced can be visually quantified by reading the traveling distance of the ink bar. This method has the potential to be used for portable and quantitative detection of a wide range of targets without any external instrument.
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Citing Literature
Special Issue:Nanotechnology & Nanomaterials, Nanotoxicology & Nanomedicine
November 10, 2014
Pages 12503-12507
