Carsten Bolm

First published: 19 February 2014

https://doi.org/10.1002/anie.201400646

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“My worst nightmare is to have to suffer from more administrative nonsense. My biggest motivation is not the h-index, for sure. …︁” This and more about Carsten Bolm can be found on page 6596–6597.

References

1“Optically Active Lactones from a Baeyer–Villiger-Type Metal-Catalyzed Oxidation with Molecular Oxygen”: C. Bolm, G. Schlingloff, K. Weickhardt, Angew. Chem. 1994, 106, 1944–1946;
10.1002/ange.19941061820
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Angew. Chem. Int. Ed. Engl. 1994, 33, 1848–1849. This is the very first report of an asymmetric Baeyer–Villiger reaction catalyzed by a chiral metal complex in an enantioselective manner. The work set the scene for various subsequent studies—by us and others—in this field, where previously only biocatalysts had successfully been applied. Perhaps we later gave up too early in this most difficult area—but other research areas proved interesting as well.
10.1002/anie.199418481
Web of Science® Google Scholar
2“Asymmetric Sulfide Oxidation with Vanadium Catalysts and H₂O₂”: C. Bolm, F. Bienewald, Angew. Chem. 1995, 107, 2883–2885;
10.1002/ange.19951072317
Web of Science® Google Scholar
Angew. Chem. Int. Ed. Engl. 1996, 34, 2640–2642. With this publication, we initiated research that later even gained industrial relevance. In subsequent work, this firstly reported catalyst system was applied and advanced worldwide. In the following years, we showed—again in Angewandte Chemie—that also an iron-based catalyst could be used for performing analogous asymmetric sulfide oxidations with hydrogen peroxide as oxidant.
10.1002/anie.199526401
CAS Web of Science® Google Scholar
3“Rhodium-Catalyzed Imination of Sulfoxides and Sulfides: Efficient Preparation of N-Unsubstituted Sulfoximines and Sulfilimines”: H. Okamura, C. Bolm, Org. Lett. 2004, 6, 1305–1308. This Communication, which at first glance appeared rather unspectacular, proved to be a “blockbuster” in sulfoximine chemistry because we introduced a new metal-catalyzed sulfur imination system that proceeded at ambient temperature. The great potential of this process was immediately recognized by industrial chemists, and today the paper is highly cited in patents related to new molecules with relevance to potential drugs and crop-protection agents.
10.1021/ol049715n
CAS PubMed Web of Science® Google Scholar
4“Base-Catalyzed Synthesis of Substituted Indazoles under Mild, Transition-Metal-Free Conditions”: I. Thomé, C. Besson, T. Kleine, C. Bolm, Angew. Chem. 2013, 125, 7657–7661;
10.1002/ange.201300917
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Angew. Chem. Int. Ed. 2013, 52, 7509–7513. Stimulated by various observations, we became engaged in transition-metal-free reactions, which led to cross-coupling-type products, very early on. In this article, we demonstrated that synthetically relevant heterocycles can be prepared—without transition metals—under very mild reaction conditions. Spectroscopic and mechanistic studies revealed the complexity of the system.
10.1002/anie.201300917
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5“Enantioselective Nitrene Transfer to Sulfides Catalyzed by a Chiral Iron Complex”: J. Wang, M. Frings, C. Bolm, Angew. Chem. 2013, 125, 8823–8827;
10.1002/ange.201304451
Web of Science® Google Scholar
Angew. Chem. Int. Ed. 2013, 52, 8661–8665. Herein, we solved a synthetic problem that relates to three research topics in the group: 1) asymmetric metal catalysis, 2) sulfur iminations, and 3) iron catalysis. The newly developed protocol allows preparing optically active sulfimides, which can then be linked to sulfoximines that are of interest for us (and others). A first breakthrough was finally achieved after many years of effort.
10.1002/anie.201304451
CAS PubMed Web of Science® Google Scholar

Volume53, Issue26

June 23, 2014

Pages 6596-6597

Carsten Bolm

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