Volume 52, Issue 46 pp. 11976-11978
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Metal/N-Heterocyclic Carbene Complexes: Opportunities for the Development of Anticancer Metallodrugs

Dr. Federico Cisnetti

Dr. Federico Cisnetti

Institut de Chimie de Clermont-Ferrand, UMR CNRS 6296, Université Blaise Pascal, BP 10448, 63000 Clermont-Ferrand (France)

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Dr. Arnaud Gautier

Corresponding Author

Dr. Arnaud Gautier

Institut de Chimie de Clermont-Ferrand, UMR CNRS 6296, Université Blaise Pascal, BP 10448, 63000 Clermont-Ferrand (France)

Institut de Chimie de Clermont-Ferrand, UMR CNRS 6296, Université Blaise Pascal, BP 10448, 63000 Clermont-Ferrand (France)Search for more papers by this author
First published: 02 October 2013
Citations: 151

Graphical Abstract

Death trap: The rational design of metal/N-heterocyclic carbene complexes allows mitochondria to be targeted. Activation of several apoptotic processes (which do not include direct DNA damage) induces cell death and significant tumor suppression.

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