Intracellular Thermometry by Using Fluorescent Gold Nanoclusters†
Dr. Li Shang
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorFlorian Stockmar
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorNaghmeh Azadfar
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorCorresponding Author
Prof. Dr. G. Ulrich Nienhaus
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany)
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA)
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/Search for more papers by this authorDr. Li Shang
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorFlorian Stockmar
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorNaghmeh Azadfar
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Search for more papers by this authorCorresponding Author
Prof. Dr. G. Ulrich Nienhaus
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen (Germany)
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA)
Institute of Applied Physics and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe (Germany) http://www.aph.kit.edu/nienhaus/Search for more papers by this authorFinancial support from the Deutsche Forschungsgemeinschaft (DFG) through the Center for Functional Nanostructures (CFN) and the Priority Program SPP1313 is gratefully acknowledged. We also thank Radian Popescu and Prof. Dr. Dagmar Gerthsen for their support with the HRTEM measurements, and Alexander Hepting for his help with building the temperature-controlled microscope sample stage.
Graphical Abstract
The “gold standard” for nanothermometry: The application of ultrasmall, near-IR-emitting fluorescent gold nanoclusters (AuNCs) for temperature sensing has been explored. AuNC-based fluorescent nanothermometry features excellent thermal sensitivity and simultaneous temperature sensing and imaging in HeLa cells.
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