Volume 52, Issue 42 pp. 11110-11113

Communication

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production^†

Laure-Estelle Cassagnes,

Laure-Estelle Cassagnes

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Vincent Hervé,

Vincent Hervé

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Prof.Dr. Françoise Nepveu,

Prof.Dr. Françoise Nepveu

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Dr. Christelle Hureau,

Dr. Christelle Hureau

Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)

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Prof.Dr. Peter Faller,

Corresponding Author

Prof.Dr. Peter Faller

[email protected]

Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)

Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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Dr. Fabrice Collin,

Corresponding Author

Dr. Fabrice Collin

[email protected]

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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Laure-Estelle Cassagnes,

Laure-Estelle Cassagnes

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Vincent Hervé,

Vincent Hervé

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Prof.Dr. Françoise Nepveu,

Prof.Dr. Françoise Nepveu

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

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Dr. Christelle Hureau,

Dr. Christelle Hureau

Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)

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Prof.Dr. Peter Faller,

Corresponding Author

Prof.Dr. Peter Faller

[email protected]

Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205, route de Narbonne (France)

Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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Dr. Fabrice Collin,

Corresponding Author

Dr. Fabrice Collin

[email protected]

Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France)

Peter Faller, Université de Toulouse; UPS, INPT, 31077 Toulouse (France)

Fabrice Collin, Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France)

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First published: 03 September 2013

https://doi.org/10.1002/anie.201305372

Citations: 107

^†

We are very grateful to C. Pestourie and the Non-Invasive Exploration service (US006/CREFRE INSERM/UPS) for the use of the γ-irradiator facility, and to L. Debrauwer and E. Jamin (Axiom facility, Metatoul, INRA) for providing the Orbitrap mass spectrometer.

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Graphical Abstract

Copper-amyloid-β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid-β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid-β peptides.

Supporting Information

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Volume52, Issue42

October 11, 2013

Pages 11110-11113

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production^†

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The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production^†