Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes†
Dr. Hahk-Soo Kang
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/
Search for more papers by this authorCorresponding Author
Prof. Sean F. Brady
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/Search for more papers by this authorDr. Hahk-Soo Kang
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/
Search for more papers by this authorCorresponding Author
Prof. Sean F. Brady
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (USA) http://lab.rockefeller.edu/brady/Search for more papers by this authorThis work was supported by NIH GM077516. S.F.B. is an HHMI Early Career Scientist. We thank Dr. José A. Salas for the generous gift of pRham.
Graphical Abstract
Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.
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