Binary Genetic Cassettes for Selecting XNA-Templated DNA Synthesis In Vivo†
Dr. Valérie Pezo
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
CEA, DSV, IG, Genoscope, 2 rue Gaston Crémieux, 91057 Evry Cedex (France)
Search for more papers by this authorDr. Feng Wu Liu
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorDr. Mikhail Abramov
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorProf. Mathy Froeyen
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorCorresponding Author
Prof. Piet Herdewijn
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)Search for more papers by this authorDr. Philippe Marlière
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
Search for more papers by this authorDr. Valérie Pezo
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
CEA, DSV, IG, Genoscope, 2 rue Gaston Crémieux, 91057 Evry Cedex (France)
Search for more papers by this authorDr. Feng Wu Liu
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorDr. Mikhail Abramov
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorProf. Mathy Froeyen
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
Search for more papers by this authorCorresponding Author
Prof. Piet Herdewijn
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, (Belgium)Search for more papers by this authorDr. Philippe Marlière
ISSB, Génopole, Genavenir6, Equipe Xénome, 5 rue Henri Desbruères, 91030 Evry Cedex (France)
Search for more papers by this authorWe thank G. Schepers for the synthesis of the oligonucleotides, Dr. J. Rozenski for mass spectrometric analysis, and Lan N’Guyen and Mélanie Crouzard for technical assistance. We thank KU Leuven (GOA, IDO), FWO (Vlaanderen) and Genoscope (Genopole, Evry) for financial support (ATIGE, EA 4527, UPS 3509). The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement n° ERC-2012-ADG_20120216/320683. XNA=xenobiotic nucleic acids.
Graphical Abstract
Hereditary information, coded in two bases, can be conveyed to DNA in vivo in the form of cyclohexenyl nucleic acid (CeNA), arabinofuranosyl nucleic acid (AraNA), and hexitol nucleic acid (HNA) messages. It was thus demonstrated that a binary genetic cassette can be used for the title process.
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