Communication

Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation^†

Dr. Nalinikanth Kotagiri

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

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Dr. Dariusz M. Niedzwiedzki,

Dr. Dariusz M. Niedzwiedzki

Photosynthetic Antenna Research Center, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA)

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Kohtaro Ohara,

Kohtaro Ohara

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

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Prof. Dr. Samuel Achilefu,

Corresponding Author

Prof. Dr. Samuel Achilefu

[email protected]

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu Search for more papers by this author

Dr. Nalinikanth Kotagiri,

Dr. Nalinikanth Kotagiri

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

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Dr. Dariusz M. Niedzwiedzki,

Dr. Dariusz M. Niedzwiedzki

Photosynthetic Antenna Research Center, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130 (USA)

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Kohtaro Ohara,

Kohtaro Ohara

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

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Prof. Dr. Samuel Achilefu,

Corresponding Author

Prof. Dr. Samuel Achilefu

[email protected]

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St. Louis, MO 63110 (USA) http://www.orl.wustl.edu Search for more papers by this author

First published: 13 June 2013

https://doi.org/10.1002/anie.201302564

Citations: 32

^†

This study was supported in part by grants from the US National Institutes of Health (NIBIB R01 EB008111, NCI R01 CA171651 and SIG 1S10RR031625-01) and the National Science Foundation (CCF 0963742). Time-resolved fluorescence and absorption experiments were performed in Ultrafast Laser Facility of the Photosynthetic Antenna Research Center (PARC), an Energy Frontier Research Center funded by the U.S. Department of Energy (DE-SC 0001035). We thank Dr. Mikhail Berezin, Dr. Monica Shokeen, Dr. Yuan-Chuan Tai, and Sergey Komarov for helpful discussions.

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Graphical Abstract

Let me get my nanoruler: Activatable probes based on radionuclide and quantum dots (QDs) were constructed using DNA as a linker. Cerenkov radiation from ⁶⁴Cu was used to excite the QDs in a distance-dependent manner. The luminescence was lowest nearest to the QD and increased with distance.

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Volume52, Issue30

July 22, 2013

Pages 7756-7760

Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation^†

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Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation†

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Activatable Probes Based on Distance-Dependent Luminescence Associated with Cerenkov Radiation^†