Multimodal Magnetic Core–Shell Nanoparticles for Effective Stem-Cell Differentiation and Imaging†
Birju Shah
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Search for more papers by this authorPerry T. Yin
Department of Biomedical Engineering, Rutgers, The State, University of New Jersey, Piscataway, NJ 08854 (USA)
Search for more papers by this authorShraboni Ghoshal
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Search for more papers by this authorCorresponding Author
Prof. Ki-Bum Lee
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/Search for more papers by this authorBirju Shah
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Search for more papers by this authorPerry T. Yin
Department of Biomedical Engineering, Rutgers, The State, University of New Jersey, Piscataway, NJ 08854 (USA)
Search for more papers by this authorShraboni Ghoshal
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Search for more papers by this authorCorresponding Author
Prof. Ki-Bum Lee
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/
Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://rutchem.rutgers.edu/∼kbleeweb/Search for more papers by this authorThis work was financially supported by the NIH Director’s Innovator Award [(1DP20D006462-01), K.B.L.] and a N.J. Commission on Spinal Cord grant [(09-3085-SCR-E-0), K.B.L.]. P.T.Y. would like to acknowledge NIH Biotechnology Training Grant for support. We would like to thank Prasad Subramaniam and Nicholas Pasquale for their useful comments on the manuscript.
Graphical Abstract
Special delivery! The title system, composed of a highly magnetic core surrounded by a thin uniform gold shell, has been synthesized and applied to the magnetically facilitated delivery of genetic material (siRNA or plasmid DNA) into neural stem cells (NSCs) for controlling their neural differentiation in a spatiotemporally controlled, biocompatible manner.
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