Volume 52, Issue 24 pp. 6326-6329

Communication

Regioselectively Functionalized Pyridines from Sustainable Resources^†

Stefan Michlik,

Stefan Michlik

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)

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Prof. Dr. Rhett Kempe,

Corresponding Author

Prof. Dr. Rhett Kempe

[email protected]

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)Search for more papers by this author

Stefan Michlik,

Stefan Michlik

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)

Search for more papers by this author

Prof. Dr. Rhett Kempe,

Corresponding Author

Prof. Dr. Rhett Kempe

[email protected]

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)

Lehrstuhl Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth (Germany)Search for more papers by this author

First published: 04 June 2013

https://doi.org/10.1002/anie.201301919

Citations: 189

^†

This project was supported by the Deutsche Forschungsgemeinschaft (DFG KE 756/23-1).

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Graphical Abstract

Make the most of it! An Ir-catalyzed dehydrogenative condensation of alcohols and 1,3-amino alcohol was used to construct pyridine derivatives regioselectively. This method provides access to unsymmetrically substituted pyridines and tolerates a wide variety of functional groups. Three equivalents of H₂ are generated per pyridine unit formed and the alcohol substrates become completely deoxygenated.

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Volume52, Issue24

June 10, 2013

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Regioselectively Functionalized Pyridines from Sustainable Resources^†