Organocatalytic Synthesis of Highly Functionalized Pyridines at Room Temperature†
Dr. Zugui Shi
Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
Search for more papers by this authorCorresponding Author
Prof. Dr. Teck-Peng Loh
Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)
Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)Search for more papers by this authorDr. Zugui Shi
Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
Search for more papers by this authorCorresponding Author
Prof. Dr. Teck-Peng Loh
Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)
Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore 637371 (Singapore)
Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Sciences and Technology of China, Hefei, Anhui 230026 (P. R. China)Search for more papers by this authorWe gratefully acknowledge the Nanyang Technological University, the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2010-T2-2-067, and MOE2011-T2-1-013) for financial support.
Graphical Abstract
Amines by all means: A unique aza-Rauhut–Currier/cyclization/desulfonation cascade reaction between allenoates and N-sulfonyl-1-aza-1,3-dienes, catalyzed by the readily available diamine TMEDA, has been developed. This strategy provides facile access to a broad range of valuable highly functionalized pyridines in good yields under very mild reaction conditions.
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