Review
The Psymberin Story—Biological Properties and Approaches towards Total and Analogue Syntheses†
Dr. Max Bielitza,
Prof. Dr. Jörg Pietruszka,
Corresponding Author
Dr. Max Bielitza
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.de
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.deSearch for more papers by this authorProf. Dr. Jörg Pietruszka
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.de
Search for more papers by this authorDr. Max Bielitza,
Prof. Dr. Jörg Pietruszka,
Corresponding Author
Dr. Max Bielitza
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.de
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.deSearch for more papers by this authorProf. Dr. Jörg Pietruszka
Institut für Bioorganische Chemie der Universität Düsseldorf im Forschungszentrum Jülich, Stetternicher Forst, Geb. 15.8, 52426 Jülich (Germany) http://www.iboc.uni-duesseldorf.de
Search for more papers by this author†
Abbreviations are given in the appendix.
Graphical Abstract
After its isolation from different sponges, the cytotoxic compound psymberin has drawn enormous attention in terms of its structure elucidation and (bio)synthesis because of its fascinating architecture and impressive biological properties. This endeavor resulted in an array of new synthetic strategies that also led to more potent analogues by altering different structural motifs.
Abstract
Psymberin is a marine natural product which has attracted a great deal of interest since its isolation: While the highly cytotoxic compound was detected early on as an ingredient in a marine sponge, it took over a decade and 600 additional samples for the structure to eventually be assigned. In the last eight years fascinating synthetic and biosynthetic investigations have led to a more detailed understanding as well as a new starting point for structure–activity studies towards new antitumor compounds. The Review gives an in-depth insight into the progress in the field of the marine polyketide psymberin and demonstrates how organic synthesis is influencing neighboring scientific subjects.
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