Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan-1†
Dr. Bo Yang
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Keisuke Yoshida
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Zhaojun Yin
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorHang Dai
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorHerbert Kavunja
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Mohammad H. El-Dakdouki
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorSuttipun Sungsuwan
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorSteven B. Dulaney
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Xuefei Huang
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)Search for more papers by this authorDr. Bo Yang
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Keisuke Yoshida
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Zhaojun Yin
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorHang Dai
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorHerbert Kavunja
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorDr. Mohammad H. El-Dakdouki
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorSuttipun Sungsuwan
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorSteven B. Dulaney
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Xuefei Huang
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)
Department of Chemistry, Michigan State University, 578 S. Shaw Lane, East Lansing, MI 48824 (USA)Search for more papers by this authorThis work was supported by the National Science Foundation (CHE 1111550) and the National Institute of General Medical Sciences, and NIH (R01GM072667).
Graphical Abstract
Finishing first: The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules.
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
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