Using Host–Guest Complexation to Fold a Flexible Linear Organic String: Kinetically Controlled Syntheses of [3]Catenanes and a Five-Membered Molecular Necklace†
Chia-Fong Chang
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorChun-Ju Chuang
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorProf. Chien-Chen Lai
Institute of Molecular Biology, National Chung Hsing University and Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan (R.O.C.)
Search for more papers by this authorYi-Hung Liu
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorProf. Shie-Ming Peng
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorCorresponding Author
Prof. Sheng-Hsien Chiu
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)Search for more papers by this authorChia-Fong Chang
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorChun-Ju Chuang
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorProf. Chien-Chen Lai
Institute of Molecular Biology, National Chung Hsing University and Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan (R.O.C.)
Search for more papers by this authorYi-Hung Liu
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorProf. Shie-Ming Peng
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Search for more papers by this authorCorresponding Author
Prof. Sheng-Hsien Chiu
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)Search for more papers by this authorWe thank the National Science Council (Taiwan) (NSC-100-2119-M-002-026 and NSC-101-2628-M-002-010) and National Taiwan University (NTU-101-R890913) for financial support.
Graphical Abstract
Rings and necklaces: Three [3]catenanes and a five-membered molecular necklace ([5]MN), with up to 60- and 92-membered rings as their centerpieces, respectively, have been synthesized. The synthesis started from the corresponding complexes in which the threaded flexible linear guests were bent at approximately right angles to facilitate kinetically controlled macrocyclizations.
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