Induced-Fit Binding of a Polyproline Helix by a β-Hairpin Peptide†
Dr. Dale J. Wilger
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorJessica H. Park
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorDr. Robert M. Hughes
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorDr. Matthew E. Cuellar
College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455 (USA)
Search for more papers by this authorCorresponding Author
Prof. Marcey L. Waters
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)Search for more papers by this authorDr. Dale J. Wilger
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorJessica H. Park
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorDr. Robert M. Hughes
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Search for more papers by this authorDr. Matthew E. Cuellar
College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455 (USA)
Search for more papers by this authorCorresponding Author
Prof. Marcey L. Waters
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)
Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599 (USA)Search for more papers by this authorThe National Science Foundation is gratefully acknowledged for funding of this research (Grant No. CHE 0716126).
Graphical Abstract
Form-fitting: The study of a minimal mimic of a protein domain that binds to type II polyproline helices through an aromatic cleft is reported. This binding motif mimics that of protein domains, including those important in disease states such as HIV infection and cancer. This study provides insight into the structure–function relationship in binding as well as quantitative data on the magnitude of prolyl–π interactions relevant to inhibitor design.
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