Communication
Ca2+ Induces the Formation of Two Distinct Subpopulations of Group II Intron Molecules†
†
This work was supported by the Swiss National Science Foundation and the University of Zurich (R.K.O.S.), as well as by the NIH and the NSF (R01 GM085996 and MCB-0747285 to D.R.).
Graphical Abstract
New wrinkles in folding: In the folding of the D135 ribozyme derived from the group II intron Sc.ai5γ, partial replacement of Mg2+ with Ca2+ leads to a division into two distinct subpopulations that are not interchangeable. The picture shows the splitting into the two types together with the single-molecule FRET states.
