Volume 48, Issue 52 pp. 9862-9866
Communication

Phospholipid-Coated Carbon Nanotubes as Sensitive Electrochemical Labels with Controlled-Assembly-Mediated Signal Transduction for Magnetic Separation Immunoassay

Huagui Nie Dr.

Huagui Nie Dr.

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P. R. China), Fax: (+86) 731-8882-1916

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Sijia Liu Dr.

Sijia Liu Dr.

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P. R. China), Fax: (+86) 731-8882-1916

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Ruqin Yu Prof.

Ruqin Yu Prof.

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P. R. China), Fax: (+86) 731-8882-1916

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Jianhui Jiang Prof. Dr.

Jianhui Jiang Prof. Dr.

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P. R. China), Fax: (+86) 731-8882-1916

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First published: 15 December 2009
Citations: 89

This work was supported by “973” National Key Basic Research Program (2007CB310500), NSFC (20875027, 20775023) and NSF of Hunan province (07JJ1002).

Graphical Abstract

A coat to note: An electrochemical immunoassay strategy is developed using phospholipid-coated multiwalled carbon nanotubes (MWNTs) as the electrochemical labels (see scheme; PSA=antigen protein; MB=magnetic bead). This strategy affords great sensitivity and specificity in signal transduction.

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