pH-Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water†
Chao Wang
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorChaoqun Li
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorXiaofeng Wu Dr.
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorAlan Pettman Dr.
Chemical R & D, Global Research & Development, Pfizer, Sandwich, Kent CT13 9NJ (UK)
Search for more papers by this authorJianliang Xiao Prof.
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorChao Wang
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorChaoqun Li
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorXiaofeng Wu Dr.
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorAlan Pettman Dr.
Chemical R & D, Global Research & Development, Pfizer, Sandwich, Kent CT13 9NJ (UK)
Search for more papers by this authorJianliang Xiao Prof.
Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK), Fax: (+44) 151-794-3589 http://pcwww.liv.ac.uk/∼jxiao
Search for more papers by this authorWe are grateful to Pfizer for funding (C.W.) and AstraZeneca for support.
Graphical Abstract
In buffered water, a broad range of quinoline derivatives underwent asymmetric transfer hydrogenation in air with the rhodium catalyst 1 and sodium formate as the hydrogen source to furnish synthetically important 1,2,3,4-tetrahydroquinolines with excellent enantioselectivities (see scheme; R=H, Me, F, Cl, Br, OMe; R′=alkyl, aryl).
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