Radicals and Transition-Metal Catalysis: An Alliance Par Excellence to Increase Reactivity and Selectivity in Organic Chemistry†
Leigh Ford Dr.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 http://www.uochb.cz/web/structure/616.html
Search for more papers by this authorUllrich Jahn Priv.-Doz. Dr.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 http://www.uochb.cz/web/structure/616.html
Search for more papers by this authorLeigh Ford Dr.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 http://www.uochb.cz/web/structure/616.html
Search for more papers by this authorUllrich Jahn Priv.-Doz. Dr.
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6 (Czech Republic), Fax: (+420) 220-183-578 http://www.uochb.cz/web/structure/616.html
Search for more papers by this authorWe gratefully acknowledge generous funding from the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic.
Graphical Abstract
Welcome to radical catalysis: Radicals are “tamed” in transition-metal complexes which serve as catalysts for a number of reactions—Kumada couplings (see scheme), highly regioselective cobalt-catalyzed eliminations, Markovnikov additions, and reductive epoxide openings catalyzed by a titanium/rhodium system. All of these reactions are powered by the high reactivity of radical intermediates in the catalytic cycle of the metal-catalyzed process.
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