Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes†
Zehui Cao Dr.
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Z.C. and R.T. contributed equally to this work.
Search for more papers by this authorRong Tong
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Z.C. and R.T. contributed equally to this work.
Search for more papers by this authorAbhijit Mishra
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorWeichen Xu
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Search for more papers by this authorGerard C. L. Wong Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorJianjun Cheng Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorYi Lu Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Search for more papers by this authorZehui Cao Dr.
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Z.C. and R.T. contributed equally to this work.
Search for more papers by this authorRong Tong
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Z.C. and R.T. contributed equally to this work.
Search for more papers by this authorAbhijit Mishra
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorWeichen Xu
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Search for more papers by this authorGerard C. L. Wong Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorJianjun Cheng Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Search for more papers by this authorYi Lu Prof.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.html http://www.matse.illinois.edu/faculty/cheng/profile.html
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html
Search for more papers by this authorThis work was supported by a National Science Foundation Nanoscale Science and Engineering Center grant (DMR-0117792). J.C. thanks support from the National Science Foundation Career Program (DMR-0748834) and the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)—Center for Nanoscale Science and Technology (CNST, UIUC).
Graphical Abstract
Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolin-aptamer-conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
| Filename | Description |
|---|---|
| anie_200901452_sm_miscellaneous_information.pdf61.1 KB | miscellaneous information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1L. Kelland, Nat. Rev. Cancer 2007, 7, 573.
- 2E. R. Jamieson, S. J. Lippard, Chem. Rev. 1999, 99, 2467.
- 3A. Rajeswaran, A. Trojan, B. Burnand, M. Giannelli, Lung Cancer 2008, 59, 1.
- 4P. J. Bednarski, R. Grunert, M. Zielzki, A. Wellner, F. S. Mackay, P. J. Sadler, Chem. Biol. 2006, 13, 61.
- 5S. Dhar, Z. Liu, J. Thomale, H. Dai, S. J. Lippard, J. Am. Chem. Soc. 2008, 130, 11467.
- 6J. W. Park, D. B. Kirpotin, K. Hong, R. Shalaby, Y. Shao, U. B. Nielsen, J. D. Marks, D. Papahadjopoulos, C. C. Benz, J. Controlled Release 2001, 74, 95.
- 7P. Sapra, T. M. Allen, Cancer Res. 2002, 62, 7190.
- 8T. A. Elbayoumi, V. P. Torchilin, Eur. J. Pharm. Sci. 2007, 32, 159.
- 9P. Sapra, T. M. Allen, Prog. Lipid Res. 2003, 42, 439.
- 10D. B. Kirpotin, D. C. Drummond, Y. Shao, M. R. Shalaby, K. Hong, U. B. Nielsen, J. D. Marks, C. C. Benz, J. W. Park, Cancer Res. 2006, 66, 6732.
- 11C. Tuerk, L. Gold, Science 1990, 249, 505.
- 12A. D. Ellington, J. W. Szostak, Nature 1990, 346, 818.
- 13M. Blank, T. Weinschenk, M. Priemer, H. Schluesener, J. Biol. Chem. 2001, 276, 16464.
- 14C. Wang, M. Zhang, G. Yang, D. Zhang, H. Ding, H. Wang, M. Fan, B. Shen, N. Shao, J. Biotechnol. 2003, 102, 15.
- 15D. A. Daniels, H. Chen, B. J. Hicke, K. M. Swiderek, L. Gold, Proc. Natl. Acad. Sci. USA 2003, 100, 15416.
- 16L. Cerchia, F. Duconge, C. Pestourie, J. Boulay, Y. Aissouni, K. Gombert, B. Tavitian, V. de Franciscis, D. Libri, PLoS Biol. 2005, 3, e 123.
- 17B. J. Hicke, C. Marion, Y. F. Chang, T. Gould, C. K. Lynott, D. Parma, P. G. Schmidt, S. Warren, J. Biol. Chem. 2001, 276, 48644.
- 18S. P. Ohuchi, T. Ohtsu, Y. Nakamura, Biochimie 2006, 88, 897.
- 19D. Shangguan, Y. Li, Z. Tang, Z. C. Cao, H. W. Chen, P. Mallikaratchy, K. Sefah, C. J. Yang, W. Tan, Proc. Natl. Acad. Sci. USA 2006, 103, 11838.
- 20K. T. Guo, R. Schafer, A. Paul, A. Gerber, G. Ziemer, H. P. Wendel, Stem Cells 2006, 24, 2220.
- 21Z. Tang, D. Shangguan, K. Wang, H. Shi, K. Sefah, P. Mallikratchy, H. W. Chen, Y. Li, W. Tan, Anal. Chem. 2007, 79, 4900.
- 22D. Shangguan, L. Meng, Z. C. Cao, Z. Xiao, X. Fang, Y. Li, D. Cardona, R. P. Witek, C. Liu, W. Tan, Anal. Chem. 2008, 80, 721.
- 23H. W. Chen, C. D. Medley, K. Sefah, D. Shangguan, Z. Tang, L. Meng, J. E. Smith, W. Tan, ChemMedChem 2008, 3, 991.
- 24M. S. Raddatz, A. Dolf, E. Endl, P. Knolle, M. Famulok, G. Mayer, Angew. Chem. 2008, 120, 5268;
10.1002/ange.200800216 Google ScholarAngew. Chem. Int. Ed. 2008, 47, 5190.
- 25O. C. Farokhzad, J. Cheng, B. A. Teply, I. Sherifi, S. Jon, P. W. Kantoff, J. P. Richie, R. Langer, Proc. Natl. Acad. Sci. USA 2006, 103, 6315.
- 26J. Cheng, B. A. Teply, I. Sherifi, J. Sung, G. Luther, F. X. Gu, E. Levy-Nissenbaum, A. F. Radovic-Moreno, R. Langer, O. C. Farokhzad, Biomaterials 2007, 28, 869.
- 27V. Bagalkot, L. Zhang, E. Levy-Nissenbaum, S. Jon, P. W. Kantoff, R. Langer, O. C. Farokhzad, Nano Lett. 2007, 7, 3065.
- 28F. Gu, L. Zhang, B. A. Teply, N. Mann, A. Wang, A. F. Radovic-Moreno, R. Langer, O. C. Farokhzad, Proc. Natl. Acad. Sci. USA 2008, 105, 2586.
- 29S. Dhar, F. X. Gu, R. Langer, O. C. Farokhzad, S. J. Lippard, Proc. Natl. Acad. Sci. USA 2008, 105, 17356.
- 30Y. Kaneda, Adv. Drug Delivery Rev. 2000, 43, 197.
- 31A. Wagner, M. Platzgummer, G. Kreismayr, H. Quendler, G. Stiegler, B. Ferko, G. Vecera, K. Vorauer-Uhl, H. Katinger, J. Liposome Res. 2006, 16, 311.
- 32M. C. Willis, B. Collins, T. Zhang, L. S. Green, D. P. Sebesta, C. Bell, E. Kellogg, S. C. Gill, A. Magallanez, S. Knauer, R. A. Bendele, P. S. Gill, N. Janjic, Bioconjugate Chem. 1998, 9, 573.
- 33Y. Matsumura, H. Maeda, Cancer Res. 1986, 46, 6387.
- 34H. Maeda, J. Wu, T. Sawa, Y. Matsumura, K. Hori, J. Controlled Release 2000, 65, 271.
- 35J. Woo, G. N. Chiu, G. Karlsson, E. Wasan, L. Ickenstein, K. Edwards, M. B. Bally, Int. J. Pharm. 2008, 349, 38.
- 36C. Mamot, D. C. Drummond, U. Greiser, K. Hong, D. B. Kirpotin, J. D. Marks, J. W. Park, Cancer Res. 2003, 63, 3154.
- 37J. M. Meerum Terwogt, G. Groenewegen, D. Pluim, M. Maliepaard, M. M. Tibben, A. Huisman, W. W. ten Bokkel Huinink, M. Schot, H. Welbank, E. E. Voest, J. H. Beijnen, J. M. Schellens, Cancer Chemother. Pharmacol. 2002, 49, 201.
- 38S. C. White, P. Lorigan, G. P. Margison, J. M. Margison, F. Martin, N. Thatcher, H. Anderson, M. Ranson, Br. J. Cancer 2006, 95, 822.
- 39C. O. Noble, D. B. Kirpotin, M. E. Hayes, C. Mamot, K. Hong, J. W. Park, C. C. Benz, J. D. Marks, D. C. Drummond, Expert Opin. Ther. Targets 2004, 8, 335.
- 40P. J. Bates, J. B. Kahlon, S. D. Thomas, J. O. Trent, D. M. Miller, J. Biol. Chem. 1999, 274, 26369.
- 41M. Srivastava, H. B. Pollard, FASEB J. 1999, 13, 1911.
- 42M. Derenzini, V. Sirri, D. Trere, R. L. Ochs, Lab. Invest. 1995, 73, 497.
- 43Y. Otake, S. Soundararajan, T. K. Sengupta, E. A. Kio, J. C. Smith, M. Pineda-Roman, R. K. Stuart, E. K. Spicer, D. J. Fernandes, Blood 2007, 109, 3069.
- 44K. Xu, R. F. Luduena, Cell Motil. Cytoskeleton 2002, 53, 39.
- 45S. Soundararajan, W. Chen, E. K. Spicer, N. Courtenay-Luck, D. J. Fernandes, Cancer Res. 2008, 68, 2358.
- 46V. Dapic, P. J. Bates, J. O. Trent, A. Rodger, S. D. Thomas, D. M. Miller, Biochemistry 2002, 41, 3676.
- 47D. Kirpotin, J. W. Park, K. Hong, S. Zalipsky, W. L. Li, P. Carter, C. C. Benz, D. Papahadjopoulos, Biochemistry 1997, 36, 66.
- 48J. W. Park, K. Hong, P. Carter, H. Asgari, L. Y. Guo, G. A. Keller, C. Wirth, R. Shalaby, C. Kotts, W. I. Wood, Proc. Natl. Acad. Sci. USA 1995, 92, 1327.
- 49J. W. Park, K. Hong, D. B. Kirpotin, G. Colbern, R. Shalaby, J. Baselga, Y. Shao, U. B. Nielsen, J. D. Marks, D. Moore, D. Papahadjopoulos, C. C. Benz, Clin. Cancer Res. 2002, 8, 1172.
- 50A. Ghezzi, M. Aceto, C. Cassino, E. Gabano, D. Osella, J. Inorg. Biochem. 2004, 98, 73.
- 51D. R. Budman, A. Calabro, W. Kreis, Anticancer Drugs 2002, 13, 1011.
- 52C. P. Rusconi, E. Scardino, J. Layzer, G. A. Pitoc, T. L. Ortel, D. Monroe, B. A. Sullenger, Nature 2002, 419, 90.
- 53C. P. Rusconi, J. D. Roberts, G. A. Pitoc, S. M. Nimjee, R. R. White, G. Quick, Jr., E. Scardino, W. P. Fay, B. A. Sullenger, Nat. Biotechnol. 2004, 22, 1423.
- 54C. K. Dyke, S. R. Steinhubl, N. S. Kleiman, R. O. Cannon, L. G. Aberle, M. Lin, S. K. Myles, C. Melloni, R. A. Harrington, J. H. Alexander, R. C. Becker, C. P. Rusconi, Circulation 2006, 114, 2490.
- 55I. Martin-Kleiner, I. Svoboda-Beusan, J. Gabrilovac, Immunopharmacol. Immunotoxicol. 2006, 28, 411.
