Volume 47, Issue 44 pp. 8344-8346
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Crystal Structure of a Molecular Assembly Line

Kira J. Weissman Dr.

Kira J. Weissman Dr.

Department of Pharmaceutical Biotechnology, Saarland University, P.O. Box 151150, 66041 Saarbrücken (Germany), Fax: (+49) 681-3027-0201

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Rolf Müller Prof.

Rolf Müller Prof.

Department of Pharmaceutical Biotechnology, Saarland University, P.O. Box 151150, 66041 Saarbrücken (Germany), Fax: (+49) 681-3027-0201

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First published: 15 October 2008
Citations: 3

This research was supported by the Bundesministerium für Bildung und Forschung and the Deutsche Forschungsgemeinschaft.

Graphical Abstract

Domain event: Non-ribosomal peptide synthetases (NRPSs) are gigantic molecular machines which assemble natural products of high structural complexity in bacteria and fungi. A team of researchers has recently solved the first crystal structure of an entire module of domains from an NRPS system, a breakthrough achievement for the field.

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