Systems Chemistry on Ribozyme Self-Construction: Evidence for Anabolic Autocatalysis in a Recombination Network
Eric J. Hayden Dr.
Department of Chemistry, Portland State University, PO Box 751, Portland, OR 97207 (USA), Fax: (+1) 503-725-8769 http://www.chem.pdx.edu/∼niles/lehman_lab_at_psu/home.html
Search for more papers by this authorGünter von Kiedrowski Prof. Dr.
Lehrstuhl für Organische Chemie I, Bioorganische Chemie, Ruhr-Universität Bochum (Germany)
Search for more papers by this authorNiles Lehman Prof.
Department of Chemistry, Portland State University, PO Box 751, Portland, OR 97207 (USA), Fax: (+1) 503-725-8769 http://www.chem.pdx.edu/∼niles/lehman_lab_at_psu/home.html
Search for more papers by this authorEric J. Hayden Dr.
Department of Chemistry, Portland State University, PO Box 751, Portland, OR 97207 (USA), Fax: (+1) 503-725-8769 http://www.chem.pdx.edu/∼niles/lehman_lab_at_psu/home.html
Search for more papers by this authorGünter von Kiedrowski Prof. Dr.
Lehrstuhl für Organische Chemie I, Bioorganische Chemie, Ruhr-Universität Bochum (Germany)
Search for more papers by this authorNiles Lehman Prof.
Department of Chemistry, Portland State University, PO Box 751, Portland, OR 97207 (USA), Fax: (+1) 503-725-8769 http://www.chem.pdx.edu/∼niles/lehman_lab_at_psu/home.html
Search for more papers by this authorGraphical Abstract
Humpty Dumpty, heal thyself: Four fragments of a catalytic RNA can autocatalytically self-assemble back into a covalently contiguous ribozyme. This reaction network (see picture) demonstrates anabolic autocatalysis in which positive feedback occurs at multiple points.
Supporting Information
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References
- 1E. Szathmáry, Philos. Trans. R. Soc. Lond. B Biol Sci. 2006, 361, 1761–1766.
- 2T. Gánti, The Principles of Life, Oxford University Press, Oxford, 2003.
10.1093/acprof:oso/9780198507260.001.0001 Google Scholar
- 3S. A. Kauffman, The Origins of Order, Oxford University Press, New York, 1993.
10.1093/oso/9780195079517.001.0001 Google Scholar
- 4P. L. Luisi, The Emergence of Life, New York, Cambridge University Press, 2006.
10.1017/CBO9780511817540 Google Scholar
- 5L. E. Orgel, Proc. Natl. Acad. Sci. USA 2000, 97, 12503–12507.
- 6A. Eschenmoser, Tetrahedron 2007, 63, 12821–12844.
- 7P. Yin, H. M. T. Choi, C. R. Calvert, N. A. Pierce, Nature 2008, 451, 318–322.
- 8D. Y. Zhang, A. T. Turberfield, B. Yurke, E. Winfree, Science 2007, 318, 1121–1125.
- 9M. Levy, A. D. Ellington, Proc. Natl. Acad. Sci. USA 2003, 100, 6416–6421.
- 10W. S. Zielinski, L. E. Orgel, Nature 1987, 327, 346–347.
- 11G. von Kiedrowski, Angew. Chem. 1986, 98, 932–934; Angew. Chem. Int. Ed. Engl. 1986, 25, 932–935.
- 12T. Achilles, G. von Kiedrowski, Angew. Chem. 1993, 105, 1225–1228; Angew. Chem. Int. Ed. Engl. 1993, 32, 1198–1201.
- 13D. Sievers, G. von Kiedrowski, Nature 1994, 369, 221–224.
- 14N. Paul, G. F. Joyce, Proc. Natl. Acad. Sci. USA 2002, 99, 12733–12740. Reported an autocatalytic efficiency of 3×108 M−1.
- 15D. H. Lee, J. R. Granja, J. A. Martinez, K. Severin, M. R. Ghadiri, Nature 1996, 382, 525–528.
- 16K. Severin, D. H. Lee, J. A. Martinez, M. Vieth, M. R. Ghadiri, Angew. Chem. 1998, 110, 133–135;
Angew. Chem. Int. Ed. 1998, 37, 126–128.
10.1002/(SICI)1521-3773(19980202)37:1/2<126::AID-ANIE126>3.0.CO;2-4 CAS Web of Science® Google Scholar
- 17T. Tjivikua, P. Ballester, J. Rebek, J. Am. Chem. Soc. 1990, 112, 1249–1250.
- 18M. Eigen, Naturwissenschaften 1971, 58, 465–528. Quotation marks are Eigen's.
- 19M. Kindermann, I. Stahl, M. Reimold, W. M. Pankau, G. von Kiedrowski, Angew. Chem. 2005, 117, 6908–6913;
10.1002/ange.200501527 Google ScholarAngew. Chem. Int. Ed. 2005, 44, 6750–6755.
- 20E. J. Hayden, N. Lehman, Chem. Biol. 2006, 13, 909–918.
- 21W. E. Draper, E. J. Hayden, N. Lehman, Nucleic Acids Res. 2008, 36, 520–531.
- 22G. von Kiedrowski, Bioorg. Chem. Front. 1993, 3, 113–146.
- 23G. von Kiedrowski, B. Wlotzka, J. Helbing, M. Mazten, M. S. Jordan, Angew. Chem. 1991, 103, 456–459; Angew. Chem. Int. Ed. Engl. 1991, 30, 423–426.
- 24B. Rangan, P. Masquida, E. Westhof, S. A. Woodson, Proc. Natl. Acad. Sci. USA 2003, 100, 1574–1579.
- 25These data or discussion can be found in the Supporting Information.
- 26N. Paul, G. F. Joyce, Curr. Opin. Chem. Biol. 2004, 8, 634–639.
- 27I. Stahl, G. von Kiedrowski, J. Am. Chem. Soc. 2006, 128, 14014–14015.
- 28L. Kuo, L. A. Davidson, S. Pico, Biochim. Biophys. Acta Gene Struct. Expression 1999, 1489, 281–292.
